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IPR039974 is a Pre-mRNA-splicing factor SLU7.
<p>The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions [[cite:PUB00090374]]. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22. ATP hydrolysis by the DEAH-box enzyme Prp16 promotes a conformational change in the spliceosome that leads to protection of the 3' splice site from targeted RNase H cleavage. This change, which probably reflects binding of the 3' splice site PyAG in the catalytic centre of the spliceosome, requires the ordered recruitment of Slu7, Prp18, and Prp22 to the spliceosome. There is a close functional relationship between Prp8, Prp18, and Slu7, and Prp18 interacts with Slu7, so that together they recruit Prp22 to the spliceosome. Most members of the family carry a zinc-finger of the CCHC-type; this retains the protein within the nucleus [[cite:PUB00090375]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Second spliceosomal transesterification activity | Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. | ||
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Molecular function | Pre-mRNA 3'-splice site binding | Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A072UDN9|A0A072UDN9_MEDTR Pre-mRNA-splicing factor SLU7-like protein; Found in the gene: LotjaGi1g1v0210600 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|I1N2J3|I1N2J3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0210600 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|A2YQU8|SLU7_ORYSI Pre-mRNA-splicing factor SLU7; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|A2YQU8|SLU7_ORYSI Pre-mRNA-splicing factor SLU7; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |