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IPR021950 is a Transcription factor Spt20.
<p>This entry represents the Spt20 transcription factors in eukaryote organisms. The Spt20 protein is a subunit of the SAGA (Spt-Ada-Gcn5-acetyltransferase) complex, a large multiprotein complex involved in transcriptional regulation. In yeast, Spt20 plays a crucial role in maintaining the structural integrity of the SAGA complex, as no intact SAGA complex could be purified in Spt20 deletion strains. It is involved in chromatin organisation, histone acetylation, and IRE1-mediated unfolded protein response [[cite:PUB00101215]]. The human homologue of Spt20 (hSPT20) has been identified as a bona fide subunit of the human SAGA complex and is required for its integrity [[cite:PUB00101216]]. Functionally, Spt20 has been shown to participate in the regulation of specific genes. In yeast, it is required for the transcriptional elongation of PDR5 and the activation of seripauperin genes upon hypoxic stress exposure [[cite:PUB00101215]]. In human cells, hSPT20 and other hSAGA subunits are specifically recruited to genes induced by endoplasmic reticulum (ER) stress [[cite:PUB00101216], [cite:PUB00101214]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | SAGA complex | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8. | ||
| Molecular function | Transcription coregulator activity | A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein FAM48A, partial [Caragana korshinskii] gi|480328083|gb|AGJ83743.1| | 3 | ||
| – | Protein FAM48A, partial [Caragana korshinskii] gi|480328083|gb|AGJ83743.1| | 3 | ||
| – | Transcription factor Spt20; TAIR: AT1G72390.1 nuclear receptor coactivator; Swiss-Prot: sp|Q8NEM7|SP20H_HUMAN Transcription factor SPT20 homolog; TrEMBL-Plants: tr|K7MEJ0|K7MEJ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0411400 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |