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IPR023186 is a Inosine/uridine-preferring nucleoside hydrolase.
<p>Inosine-uridine preferring nucleoside hydrolase ([ec:3.2.2.1]) (IU-nucleoside hydrolase or IUNH) is an enzyme first identified in protozoan [[cite:PUB00000434]] that catalyses the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. This enzyme is important for these parasitic organisms, which are deficient in<i>de novo</i>synthesis of purines, to salvage the host purine nucleosides. IUNH from Crithidia fasciculata has been sequenced and characterised, it is an homotetrameric enzyme of subunits of 34 Kd. An histidine has been shown to be important for the catalytic mechanism, it acts as a proton donor to activate the hypoxanthine leaving group.</p> <p>A highly conserved region located in the N-terminal extremity contains four conserved aspartates that have been shown [[cite:PUB00000435]] to be located in the active site cavity.</p> <p>IUNH is evolutionary related to a number of uncharacterised proteins from various biological sources.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Inosine-uridine preferring ribonucleoside hydrolase [Medicago truncatula] gi|357510999|ref|XP_003625788.1| | 8 | ||
| – | Inosine-uridine preferring nucleoside hydrolase family protein isoform 2 [Theobroma cacao] gi|508714449|gb|EOY06346.1| | 15 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase rihB [Medicago truncatula] gi|357478551|ref|XP_003609561.1| | 15 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase rihA [Medicago truncatula] gi|357447543|ref|XP_003594047.1| | 7 | ||
| – | Inosine-uridine preferring nucleoside hydrolase family protein isoform 2 [Theobroma cacao] gi|508714449|gb|EOY06346.1| | 14 | ||
| – | Inosine-uridine preferring nucleoside hydrolase family protein isoform 2 [Theobroma cacao] gi|508714449|gb|EOY06346.1| | 14 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase; TAIR: AT2G36310.1 uridine-ribohydrolase 1; Swiss-Prot: sp|Q9SJM7|URH1_ARATH Uridine nucleosidase 1; TrEMBL-Plants: tr|A0A151TVS2|A0A151TVS2_CAJCA Uncharacterized protein C1683.06c family; Found in the gene: LotjaGi1g1v0677200 | 9 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase; TAIR: AT1G05620.2 uridine-ribohydrolase 2; Swiss-Prot: sp|Q8LAC4|URH2_ARATH Probable uridine nucleosidase 2; TrEMBL-Plants: tr|V7C4D6|V7C4D6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0062700 | 9 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase; TAIR: AT1G05620.1 uridine-ribohydrolase 2; Swiss-Prot: sp|Q8LAC4|URH2_ARATH Probable uridine nucleosidase 2; TrEMBL-Plants: tr|V7C4D6|V7C4D6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0062700 | 9 | ||
| – | Pyrimidine-specific ribonucleoside hydrolase; TAIR: AT1G05620.1 uridine-ribohydrolase 2; Swiss-Prot: sp|Q8LAC4|URH2_ARATH Probable uridine nucleosidase 2; TrEMBL-Plants: tr|V7C4D6|V7C4D6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0062700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02650 | CDD | 1 | 10.00 |