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IPR024177 is a Biotin synthase.
<p>This family consists of biotin synthase B-like proteins.</p> <p>Biotin synthase [ec:2.8.1.6] works with flavodoxin, S-adenosylmethionine, and possibly cysteine to catalyze the last step of the biotin biosynthetic pathway. The reaction consists of the introduction of a sulphur atom into dethiobiotin, thus requiring activation of C-H bonds [[cite:PUB00002298]]. Biotin (vitamin H) is a prosthetic group in enzymes catalysing carboxylation and transcarboxylation reactions [[cite:PUB00001863]].</p> <p>Biotin synthase from Escherichia coli is a homodimer of 76kDa, with each polypeptide chain carrying an oxygen-sensitive (4Fe-4S) cluster, probably ligated by three cysteines of a CXXXCXXC box conserved among all known BioB sequences and a fourth still not identified ligand. BioB displays a pyridoxal phosphate-dependent cysteine desulphurase activity, which allows mobilisation of the sulphur atom from free cysteine [[cite:PUB00007197]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Biotin synthase [Medicago truncatula] gi|357474135|ref|XP_003607352.1| | 21 | ||
| – | Biotin synthase; TAIR: AT2G43360.1 Radical SAM superfamily protein; Swiss-Prot: sp|P54967|BIOB_ARATH Biotin synthase; TrEMBL-Plants: tr|A0A1J7GGN8|A0A1J7GGN8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535800 | 20 | ||
| – | Biotin synthase; TAIR: AT2G43360.1 Radical SAM superfamily protein; Swiss-Prot: sp|P54967|BIOB_ARATH Biotin synthase; TrEMBL-Plants: tr|A0A1J7GGN8|A0A1J7GGN8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535800 | 20 | ||
| – | Biotin synthase; TAIR: AT2G43360.1 Radical SAM superfamily protein; Swiss-Prot: sp|P54967|BIOB_ARATH Biotin synthase; TrEMBL-Plants: tr|A0A1J7GGN8|A0A1J7GGN8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535800 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01335 | CDD | 1 | 25.00 |