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IPR024687 is a MMS19, C-terminal.
<p>This entry represents the C-terminal domain of MMS19. This domain shares homology with some HEAT repeat sequences. MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity [[cite:PUB00069922], [cite:PUB00069921], [cite:PUB00098185]].</p> <p>In humans, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription [[cite:PUB00069922], [cite:PUB00069921]]. It is also part of the MMXD (MMS19-MIP18-XPD) complex, which plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD [[cite:PUB00068842]].</p> <p>In budding yeasts, the mms19 mutants were originally isolated in a screening for mutants hypersensitive to the alkylating agent methyl methanesulfonate (MMS) [[cite:PUB00069925]]. Different from human MMS19, Mms19 in budding yeasts (also known as Met18) does not participate directly in NER [[cite:PUB00068841]].</p> <p>In fission yeast, Mms19 is part of a silencing complex named Rik1-Dos2 complex, which contains Dos2, Rik1, Mms19 and Cdc20. This complex regulates RNA Pol II activity in heterochromatin, and is required for DNA replication and heterochromatin assembly [[cite:PUB00066660]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | MMS19 nucleotide excision repair protein-like protein [Medicago truncatula] gi|357454787|ref|XP_003597674.1| | 7 | ||
| – | MMS19 nucleotide excision repair protein like; TAIR: AT5G48120.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0WVF8|MMS19_ARATH MMS19 nucleotide excision repair protein homolog; TrEMBL-Plants: tr|K7M923|K7M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0202000 | 10 | ||
| – | MMS19 nucleotide excision repair protein like; TAIR: AT5G48120.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0WVF8|MMS19_ARATH MMS19 nucleotide excision repair protein homolog; TrEMBL-Plants: tr|K7M923|K7M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0202000 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 33.33 |