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IPR039920

Source: InterPro

Description

IPR039920 is a DNA repair/transcription protein MMS19.

<p>MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity [[cite:PUB00069922], [cite:PUB00069921]]. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription [[cite:PUB00069921], [cite:PUB00069922], [cite:PUB00068841], [cite:PUB00156043]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0097428
Biological process Protein maturation by iron-sulfur cluster transfer The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0202000.1
– MMS19 nucleotide excision repair protein like; TAIR: AT5G48120.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0WVF8|MMS19_ARATH MMS19 nucleotide excision repair protein homolog; TrEMBL-Plants: tr|K7M923|K7M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0202000
Domains
10
LotjaGi1g1v0202000.2
– MMS19 nucleotide excision repair protein like; TAIR: AT5G48120.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0WVF8|MMS19_ARATH MMS19 nucleotide excision repair protein homolog; TrEMBL-Plants: tr|K7M923|K7M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0202000
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 50.00