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IPR025774 is a SAM-dependent methyltransferase gTMT-type.
<p>This entry represents a subgroup of the class I SAM-dependent methyltransferases, including bacterial 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase [[cite:PUB00074807]] and plant plastid tocopherol O-methyltransferase (also known as g-TMT (gamma-tocopherol methyltransferase)). Tocopherol O-methyltransferase is involved in the synthesis of tocopherol (vitamin E). It methylates gamma- and delta-tocopherol to form beta- and alpha-tocopherol, respectively [[cite:PUB00057990], [cite:PUB00057991], [cite:PUB00057992]]. This family also includes 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase, an homologue of tocopherol methyltransferases involved in vindoline biosynthesis [[cite:PUB00087309]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. | ||
| Biological process | Methylation | The process in which a methyl group is covalently attached to a molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Gamma-tocopherol methyltransferase [Lotus japonicus] gi|66732623|gb|AAY52459.1| | 10 | ||
| – | Gamma-tocopherol methyltransferase [Lotus japonicus] gi|66732623|gb|AAY52459.1| | 16 | ||
| – | Gamma-tocopherol methyltransferase; TAIR: AT1G64970.1 gamma-tocopherol methyltransferase; Swiss-Prot: sp|Q9ZSK1|GTOMC_ARATH Tocopherol O-methyltransferase, chloroplastic; TrEMBL-Plants: tr|Q4U3Z5|Q4U3Z5_LOTJA Gamma-tocopherol methyltransferase; Found in the gene: LotjaGi2g1v0263300_LC | 10 | ||
| – | Methyltransferase; TAIR: AT1G64970.1 gamma-tocopherol methyltransferase; Swiss-Prot: sp|Q6ZIK0|GTOMC_ORYSJ Probable tocopherol O-methyltransferase, chloroplastic; TrEMBL-Plants: tr|Q4U3Z5|Q4U3Z5_LOTJA Gamma-tocopherol methyltransferase; Found in the gene: LotjaGi3g1v0543900 | 16 | ||
| – | Methyltransferase; TAIR: AT1G64970.1 gamma-tocopherol methyltransferase; Swiss-Prot: sp|Q6ZIK0|GTOMC_ORYSJ Probable tocopherol O-methyltransferase, chloroplastic; TrEMBL-Plants: tr|Q4U3Z5|Q4U3Z5_LOTJA Gamma-tocopherol methyltransferase; Found in the gene: LotjaGi3g1v0543900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 20.00 |