Description

IPR025794 is a Histone H3-K9 methyltransferase, plant.

<p>In general, members of this family methylate 'Lys-9' of histone H3. It also methylates 'Lys-27' of histone H3 [[cite:PUB00058058]] and 'Lys-20' of H4, and cytosine [[cite:PUB00058059]]. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression [[cite:PUB00058060]].</p> <p>This enzyme plays a central role in gene silencing [[cite:PUB00058061]]. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an heterochromatin protein 1-like adapter. Arabidopsis homologue SUVH4 is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. It is also involved in the silencing of transposable elements [[cite:PUB00058062], [cite:PUB00058063], [cite:PUB00058064], [cite:PUB00058065], [cite:PUB00058066]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: