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IPR025834

Source: InterPro

Description

IPR025834 is a Topoisomerase I C-terminal domain.

<p>This domain is found at the C terminus of topoisomerase I.</p> <p>DNA topoisomerase I ([ec:5.99.1.2]) [[cite:PUB00001050], [cite:PUB00001088], [cite:PUB00004680], [cite:PUB00005437]] is one of the two types of enzyme that catalyze the interconversion of topological DNA isomers. Type I topoisomerases act by catalyzing the transient breakage of DNA, one strand at a time, and the subsequent rejoining of the strands. When a eukaryotic type 1 topoisomerase breaks a DNA backbone bond, it simultaneously forms a protein-DNA link where the hydroxyl group of a tyrosine residue is joined to a 3'-phosphate on DNA, at one end of the enzyme-severed DNA strand. In eukaryotes and poxvirus topoisomerases I, there are a number of conserved residues in the region around the active site tyrosine [[cite:PUB00004680]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj3g3v3639920.1
– Topoisomerase I [Pisum sativum] gi|2330649|emb|CAA74890.1|
Domains
29
LotjaGi3g1v0544200.1
– DNA topoisomerase 1; TAIR: AT5G55310.1 DNA topoisomerase 1 beta; Swiss-Prot: sp|Q9FJ79|TOP1B_ARATH DNA topoisomerase 1 beta; TrEMBL-Plants: tr|I1LP26|I1LP26_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0544200
Domains
30
LotjaGi3g1v0544200.2
– DNA topoisomerase 1; TAIR: AT5G55310.1 DNA topoisomerase 1 beta; Swiss-Prot: sp|Q9FJ79|TOP1B_ARATH DNA topoisomerase 1 beta; TrEMBL-Plants: tr|A0A1J7GEG9|A0A1J7GEG9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0544200
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33