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IPR026113

Description

IPR026113 is a tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like.

<p>This family includes tRNA N(3)-methylcytidine methyltransferases METTL2, 6 and 8, O-methyltransferase 3 and methyltransferase-like protein Metl from Drosophila. These proteins are S-adenosyl-L-methionine-dependent methyltransferases that mediate N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) and tRNA(Ser) [[cite:PUB00100775], [cite:PUB00100777], [cite:PUB00100776], [cite:PUB00100778], [cite:PUB00100781], [cite:PUB00100780], [cite:PUB00100779]].</p> <p>tRNA N(3)-methylcytidine methyltransferase METTL2, 6 and 8 are part of a group of proteins known as TIPs (from tension-induced/inhibited protein) required for the recruitment of histone acetyltransferase p300 to specific promoters. TIP-6 is involved in the adipogenic cascade [[cite:PUB00060039]]. O-methyltransferase 3 is up-regulated by phagocytic stimuli [[cite:PUB00060048]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Methyltransferase-like protein [Medicago truncatula] gi|357437371|ref|XP_003588961.1| 11
Methyltransferase-like protein [Medicago truncatula] gi|357437371|ref|XP_003588961.1| 9
PREDICTED: methyltransferase-like protein 6-like [Glycine max] gi|356535222|ref|XP_003536147.1| 9
PREDICTED: methyltransferase-like protein 6-like [Cicer arietinum] gi|502116710|ref|XP_004495562.1| 6
Methyltransferase; TAIR: AT2G26200.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q6AXU8|METL6_RAT Methyltransferase-like protein 6; TrEMBL-Plants: tr|A0A151SVB8|A0A151SVB8_CAJCA Methyltransferase-like protein 6; Found in the gene: LotjaGi5g1v0044800 11
Methyltransferase; TAIR: AT1G54650.1 Methyltransferase family protein; Swiss-Prot: sp|Q6AXU8|METL6_RAT Methyltransferase-like protein 6; TrEMBL-Plants: tr|A0A0R4J499|A0A0R4J499_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0206500 8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02440 CDD 1 16.67