Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR026113 is a tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like.
<p>This family includes tRNA N(3)-methylcytidine methyltransferases METTL2, 6 and 8, O-methyltransferase 3 and methyltransferase-like protein Metl from Drosophila. These proteins are S-adenosyl-L-methionine-dependent methyltransferases that mediate N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) and tRNA(Ser) [[cite:PUB00100775], [cite:PUB00100777], [cite:PUB00100776], [cite:PUB00100778], [cite:PUB00100781], [cite:PUB00100780], [cite:PUB00100779]].</p> <p>tRNA N(3)-methylcytidine methyltransferase METTL2, 6 and 8 are part of a group of proteins known as TIPs (from tension-induced/inhibited protein) required for the recruitment of histone acetyltransferase p300 to specific promoters. TIP-6 is involved in the adipogenic cascade [[cite:PUB00060039]]. O-methyltransferase 3 is up-regulated by phagocytic stimuli [[cite:PUB00060048]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Methyltransferase-like protein [Medicago truncatula] gi|357437371|ref|XP_003588961.1| | 11 | ||
| – | Methyltransferase-like protein [Medicago truncatula] gi|357437371|ref|XP_003588961.1| | 9 | ||
| – | PREDICTED: methyltransferase-like protein 6-like [Glycine max] gi|356535222|ref|XP_003536147.1| | 9 | ||
| – | PREDICTED: methyltransferase-like protein 6-like [Cicer arietinum] gi|502116710|ref|XP_004495562.1| | 6 | ||
| – | Methyltransferase; TAIR: AT2G26200.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q6AXU8|METL6_RAT Methyltransferase-like protein 6; TrEMBL-Plants: tr|A0A151SVB8|A0A151SVB8_CAJCA Methyltransferase-like protein 6; Found in the gene: LotjaGi5g1v0044800 | 11 | ||
| – | Methyltransferase; TAIR: AT1G54650.1 Methyltransferase family protein; Swiss-Prot: sp|Q6AXU8|METL6_RAT Methyltransferase-like protein 6; TrEMBL-Plants: tr|A0A0R4J499|A0A0R4J499_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0206500 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 16.67 |