Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR026126 is a BRISC and BRCA1-A complex member 1.
<p>BRISC and BRCA1-A complex member 1 (BABAM1, also known as MERIT40 and NBA1) was initially identified as a gene required for resistance to ionizing radiation [[cite:PUB00054088]]. It is a component of the BRCA1-A complex, which also contains Brca1/Bard1, Abra1, RAP80, BRCC36, and BRE [[cite:PUB00054088]]. The BRCA1-A complex recognises 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), facilitating DNA damage repair. The BRCA1-A complex is also involved in G2/M transition DNA damage checkpoint control. BABAM1 may also play a role as a component of the BRISC complex (contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins), a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, BABAM1 is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component [[cite:PUB00060076], [cite:PUB00060688]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Positive regulation of DNA repair | Any process that activates or increases the frequency, rate or extent of DNA repair. | ||
| Cellular component | BRCA1-A complex | A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. | ||
| Cellular component | BRISC complex | A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein TCM_037260 [Theobroma cacao] gi|508782602|gb|EOY29858.1| | 6 | ||
| – | Uncharacterized protein TCM_037260 [Theobroma cacao] gi|508782602|gb|EOY29858.1| | 5 | ||
| – | BRISC and BRCA1-A complex member 1; TAIR: AT4G32960.1 BRISC/BRCA1-A complex protein; Swiss-Prot: sp|Q6DJG6|BABA1_XENLA BRISC and BRCA1-A complex member 1; TrEMBL-Plants: tr|I3SNG0|I3SNG0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0366100 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |