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IPR026584 is a Rad9.
<p>This entry includes DNA damage checkpoint proteins Rad9. Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage [[cite:PUB00020219]]. It is worth noting that this entry including the mamalian Rad9, which is homologous to the fission yeast Rad9 and the budding yeast Ddc1. Members of this family do not share the sequence homology with the budding yeast Rad9.</p> <p>Rad9 forms a complex with Hus1 and Rad1, called 9-1-1 complex. In human, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway [[cite:PUB00062277]]. Rad9 also shows 3'-5' exonuclease activity [[cite:PUB00062279]]. Besides its function in the 9-1-1 complex, Rad9 can act as a transcriptional factor, participate in immunoglobulin class switch recombination [[cite:PUB00062280]]. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [[cite:PUB00060720]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | DNA damage checkpoint | A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Cellular component | Checkpoint clamp complex | Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cell cycle checkpoint control protein RAD9A-like isoform X1 [Cicer arietinum] gi|502113277|ref|XP_004494598.1| | 9 | ||
| – | Cell cycle checkpoint control family protein; TAIR: AT3G05480.1 cell cycle checkpoint control protein family; Swiss-Prot: sp|Q9Z0F6|RAD9A_MOUSE Cell cycle checkpoint control protein RAD9A; TrEMBL-Plants: tr|G7KXM9|G7KXM9_MEDTR Cell cycle checkpoint control RAD9A-like protein; Found in the gene: LotjaGi1g1v0770900 | 9 | ||
| – | Cell cycle checkpoint control family protein; TAIR: AT3G05480.1 cell cycle checkpoint control protein family; Swiss-Prot: sp|Q9Z0F6|RAD9A_MOUSE Cell cycle checkpoint control protein RAD9A; TrEMBL-Plants: tr|G7KXM9|G7KXM9_MEDTR Cell cycle checkpoint control RAD9A-like protein; Found in the gene: LotjaGi1g1v0770900 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |