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GO:0030896

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Checkpoint clamp complex
Full defintion Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
Subterm of

Relationships

The relationship of GO:0030896 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
DNA structure dependent checkpoints as regulators of DNA repair.Carr AM
DNA Repair (Amst). 2002 Dec 5; 1 (12): 983–94.PMID: 12531008

Checkpoint proteins were initially identified because their loss of function resulted in defects in cell cycle arrest in response to genotoxic treatments. Initially, the analysis of checkpoint pathways concentrated on their function as signal transducers and how the checkpoint signals were communicated to the core cell cycle machinery and transcriptional apparatus. Although some of the early genetic analysis indicated a complex relationship between DNA replication, DNA repair and the checkpoint pathways, it is only now becoming apparent that checkpoint proteins regulate multiple DNA repair and replication functions. Furthermore, recent data suggest that some checkpoint proteins may participate directly in DNA repair events. In this review I summarise the current models for DNA structure-dependent checkpoint activation and review the evidence linking checkpoint proteins both directly and indirectly to DNA repair.

Associated Lotus transcripts 8

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v4919900.1
– PREDICTED: cell cycle checkpoint control protein RAD9A-like isoform X1 [Cicer arietinum] gi|502113277|ref|XP_004494598.1|
GO terms
2
Lj1g3v4919900.2
– PREDICTED: cell cycle checkpoint control protein RAD9A-like isoform X1 [Cicer arietinum] gi|502113277|ref|XP_004494598.1|
GO terms
3
Lj2g3v1068970.1
– F6D8.25 [Theobroma cacao] gi|508778644|gb|EOY25900.1|
GO terms
3
LotjaGi1g1v0770900.1
– Cell cycle checkpoint control family protein; TAIR: AT3G05480.1 cell cycle checkpoint control protein family; Swiss-Prot: sp|Q9Z0F6|RAD9A_MOUSE Cell cycle checkpoint control protein RAD9A; TrEMBL-Plants: tr|G7KXM9|G7KXM9_MEDTR Cell cycle checkpoint control RAD9A-like protein; Found in the gene: LotjaGi1g1v0770900
GO terms
3
LotjaGi1g1v0770900.2
– Cell cycle checkpoint control family protein; TAIR: AT3G05480.1 cell cycle checkpoint control protein family; Swiss-Prot: sp|Q9Z0F6|RAD9A_MOUSE Cell cycle checkpoint control protein RAD9A; TrEMBL-Plants: tr|G7KXM9|G7KXM9_MEDTR Cell cycle checkpoint control RAD9A-like protein; Found in the gene: LotjaGi1g1v0770900
GO terms
3
LotjaGi2g1v0262500.1
– Hus1-like protein; TAIR: AT1G52530.1 Hus1-like protein; Swiss-Prot: sp|Q54NC0|HUS1_DICDI Checkpoint protein hus1 homolog; TrEMBL-Plants: tr|I3SJI1|I3SJI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0262500
GO terms
3
LotjaGi2g1v0262500.2
– Hus1-like protein; TAIR: AT1G52530.1 Hus1-like protein; Swiss-Prot: sp|Q54NC0|HUS1_DICDI Checkpoint protein hus1 homolog; TrEMBL-Plants: tr|I3SJI1|I3SJI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0262500
GO terms
3
LotjaGi2g1v0262500.3
– Hus1-like protein; TAIR: AT1G52530.1 Hus1-like protein; Swiss-Prot: sp|Q54NC0|HUS1_DICDI Checkpoint protein hus1 homolog; TrEMBL-Plants: tr|I3SJI1|I3SJI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0262500
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0030896
Cellular component Checkpoint clamp complex 1 12.50