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IPR026740 is a AP-3 complex subunit beta.
<p>The AP-3 complex functions in cargo-selective protein transport from the Golgi to the vacuole/lysosome [[cite:PUB00061731]]. It is an adapter-related complex which is thought not to be clathrin-associated. The AP-3 complex facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It is required for the transport via the ALP pathway [[cite:PUB00061732]]. In neurons, AP-3 generates synaptic vesicles or vesicles carrying synaptic vesicle membrane proteins [[cite:PUB00061733]].</p> <p>This entry represents the beta subunit of the AP-3 complex.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. | ||
| Cellular component | AP-3 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: AP3-complex subunit beta-A-like [Glycine max] gi|356501063|ref|XP_003519348.1| | 13 | ||
| – | PREDICTED: AP3-complex subunit beta-A-like [Glycine max] gi|356501063|ref|XP_003519348.1| | 13 | ||
| – | Beta-adaptin-like protein; TAIR: AT3G55480.2 protein affected trafficking 2; Swiss-Prot: sp|Q9M2T1|AP3BA_ARATH AP3-complex subunit beta-A; TrEMBL-Plants: tr|K7KAL6|K7KAL6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0090500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |