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IPR026873 is a Geranylgeranyl transferase type-2 subunit beta.
<p>This entry includes the beta subunit of geranylgeranyl transferase type-2 (GGTase-II), which is also known as Rab geranyl-geranyltransferase subunit beta, Bet2 and Ptb1. GGTase-II catalyses the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC [[cite:PUB00061963], [cite:PUB00061964], [cite:PUB00061965]]. GGTase-IIs are a subgroup of protein prenyltransferases (PTases) of lipid-modifying enzymes. PTases catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C terminus of protein acceptors and the C1 atom of isoprenoid lipids (geranylgeranyl (20-carbon) in the case of GGTase-II). GGTase-II catalyzes alkylation of both cysteine residues in Rab proteins containing carboxy-terminal "CC", "CXCX" or "CXC" motifs. PTases are heterodimeric with both alpha and beta subunits required for catalytic activity. The beta subunit has an α6-α6 barrel fold. In contrast to other prenyltransferases, GGTas-II requires an escort protein to bring the substrate protein to the catalytic heterodimer and to escort the geryanylgeranylated product to the membrane [[cite:PUB00080791], [cite:PUB00080792]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Rab geranylgeranyltransferase activity | Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. | ||
| Biological process | Protein geranylgeranylation | The covalent attachment of a geranylgeranyl group to a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| | 9 | ||
| – | PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| | 9 | ||
| – | PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| | 9 | ||
| – | Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0372600 | 9 | ||
| – | Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0379700 | 9 | ||
| – | Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0379700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02894 | CDD | 1 | 16.67 |