Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR026873

Description

IPR026873 is a Geranylgeranyl transferase type-2 subunit beta.

<p>This entry includes the beta subunit of geranylgeranyl transferase type-2 (GGTase-II), which is also known as Rab geranyl-geranyltransferase subunit beta, Bet2 and Ptb1. GGTase-II catalyses the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC [[cite:PUB00061963], [cite:PUB00061964], [cite:PUB00061965]]. GGTase-IIs are a subgroup of protein prenyltransferases (PTases) of lipid-modifying enzymes. PTases catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C terminus of protein acceptors and the C1 atom of isoprenoid lipids (geranylgeranyl (20-carbon) in the case of GGTase-II). GGTase-II catalyzes alkylation of both cysteine residues in Rab proteins containing carboxy-terminal "CC", "CXCX" or "CXC" motifs. PTases are heterodimeric with both alpha and beta subunits required for catalytic activity. The beta subunit has an α6-α6 barrel fold. In contrast to other prenyltransferases, GGTas-II requires an escort protein to bring the substrate protein to the catalytic heterodimer and to escort the geryanylgeranylated product to the membrane [[cite:PUB00080791], [cite:PUB00080792]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Rab geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
Biological process Protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| 9
PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| 9
PREDICTED: geranylgeranyl transferase type-2 subunit beta-like [Cicer arietinum] gi|502140826|ref|XP_004504351.1| 9
Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0372600 9
Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0379700 9
Geranylgeranyl transferase type-2 subunit beta; TAIR: AT5G12210.1 RAB geranylgeranyl transferase beta subunit 1; Swiss-Prot: sp|Q84J75|PGTB1_ARATH Geranylgeranyl transferase type-2 subunit beta 1; TrEMBL-Plants: tr|A0A0B2SUM0|A0A0B2SUM0_GLYSO Geranylgeranyl transferase type-2 subunit beta; Found in the gene: LotjaGi4g1v0379700 9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02894 CDD 1 16.67