Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR027054

Source: InterPro

Description

IPR027054 is a Mannosyltransferase ALG2.

<p>ALG2 mannosylates Man2GlcNAc(2)-dolichol diphosphate and Man1GlcNAc(2)-dolichol diphosphate to form Man3GlcNAc(2)-dolichol diphosphate [[cite:PUB00062782]].</p> <p>Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterised by under-glycosylated serum proteins [[cite:PUB00062782]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004378
Molecular function GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.
Subterm of
GO:0006486
Biological process Protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
Subterm of
Part of

Associated Lotus transcripts 11

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0244100.1
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.2
– Sucrose synthase 3; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q9H553|ALG2_HUMAN Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
8
LotjaGi3g1v0244100.3
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.4
– Alpha-1,3/1,6-mannosyltransferase ALG2-like protein; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|A0A151S9A8|A0A151S9A8_CAJCA Alpha-1,3-mannosyltransferase ALG2; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.5
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.6
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.7
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
14
LotjaGi3g1v0244100.8
– Sucrose synthase 3; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q9H553|ALG2_HUMAN Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|I1M2Z7|I1M2Z7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0244100
Domains
12
LotjaGi6g1v0074800.1
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0074800
Domains
15
LotjaGi6g1v0074800.2
– Sucrose synthase 3; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q9H553|ALG2_HUMAN Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|I1M2Z7|I1M2Z7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0074800
Domains
13
LotjaGi6g1v0074800.3
– Alpha-1,3-mannosyltransferase, putative; TAIR: AT1G78800.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|Q7KWM5|ALG2_DICDI Alpha-1,3/1,6-mannosyltransferase ALG2; TrEMBL-Plants: tr|C6TI07|C6TI07_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0074800
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03805 CDD 1 9.09