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IPR027120 is a Smc2, ATP-binding cassette domain.
<p>Structural maintenance of chromosomes protein 2 (Smc2) is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [[cite:PUB00062097], [cite:PUB00010072], [cite:PUB00062950], [cite:PUB00062951]].</p> <p>Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases [[cite:PUB00080850], [cite:PUB00013904]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: structural maintenance of chromosomes protein 2-1-like [Cicer arietinum] gi|502158009|ref|XP_004510992.1| | 16 | ||
| – | Structural maintenance of chromosomes protein; TAIR: AT5G62410.1 structural maintenance of chromosomes 2; Swiss-Prot: sp|Q9C5Y4|SMC21_ARATH Structural maintenance of chromosomes protein 2-1; TrEMBL-Plants: tr|A0A072TZX1|A0A072TZX1_MEDTR Structural maintenance of chromosomes protein; Found in the gene: LotjaGi3g1v0061500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03273 | CDD | 1 | 50.00 |