Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR027503

Description

IPR027503 is a Lon protease homologue, chloroplastic/mitochondrial.

<p>Lon protease is an ATP-dependent serine proteases that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins [[cite:PUB00062807]]. Proteins in this entry are the eukaryotic homologues of the Lon protease that localise at the mitochondrial matrix. They may also have a chaperone function in the assembly of inner membrane protein complexes. They may participate in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome [[cite:PUB00064768]]. In plants, they also localise at the chloroplast [[cite:PUB00064774]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Biological process Protein quality control for misfolded or incompletely synthesized proteins The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
PREDICTED: lon protease homolog 1, mitochondrial-like [Glycine max] gi|356533540|ref|XP_003535321.1| 32
Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900 36
Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900 36
Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900 37
Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900 37
Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900 38

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67