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IPR008269

Source: InterPro

Description

IPR008269 is a Peptidase S16, Lon proteolytic domain.

<p>Lon (also known as endopeptidase La) is a multi-domain ATP- dependent protease found throughout all kingdoms of life. It is involved in protein quality control and several regulatory processes. All Lon proteases contain an ATPase domain belonging to the AAA+ superfamily of molecular machines, and a proteolytic domain with a serine-lysine catalytic dyad in which a lysine assists the catalytic serine in proteolytic cleavage. Lon proteases can be divided into two subfamilies: A type (A-Lons), which have a large multi-lobed N-terminal domain together with the ATPase and protease domains, and B type (B-Lons), which lack an N domain, but have a membrane-anchoring region emerging from the ATPase domain. B-Lons are found in Archaea, in which they are the lone membrane-anchored ATP-dependent protease. The soluble A-Lons are found in all bacteria and in eukaryotic cell organelles, such as mitochondria and peroxisomes, and are needed for recovery from various stress conditions [[cite:PUB00030777], [cite:PUB00038301], [cite:PUB00038694], [cite:PUB00075692], [cite:PUB00084291], [cite:PUB00084292]]. The Lon proteolytic domain forms peptidase family S16 of clan SJ [[cite:PUB00038694]].</p> <p>The structure of the Lon proteolytic domain consists of six α helices and ten β strands [[cite:PUB00030777], [cite:PUB00038301], [cite:PUB00038694], [cite:PUB00075692], [cite:PUB00084291]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004176
Molecular function ATP-dependent peptidase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.
Subterm of
GO:0004252
Molecular function Serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Subterm of
GO:0006508
Biological process Proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Subterm of

Associated Lotus transcripts 19

Transcript Name Description Predicted domains Domain count
Lj0g3v0061699.1
– PREDICTED: lon protease homolog 2, peroxisomal-like [Glycine max] gi|356563427|ref|XP_003549964.1|
Domains
24
Lj0g3v0183909.1
– PREDICTED: lon protease homolog 1, mitochondrial-like [Glycine max] gi|356533540|ref|XP_003535321.1|
Domains
32
Lj2g3v1988690.1
– PREDICTED: lon protease homolog 2, peroxisomal-like [Cicer arietinum] gi|502160472|ref|XP_004511756.1|
Domains
32
Lj2g3v1988690.2
– PREDICTED: lon protease homolog 2, peroxisomal-like [Cicer arietinum] gi|502160472|ref|XP_004511756.1|
Domains
30
LotjaGi2g1v0417300.1
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|G7JYP5|G7JYP5_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi2g1v0417300
Domains
36
LotjaGi2g1v0417300.2
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O64948|LONP2_ARATH Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|G7JYP5|G7JYP5_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi2g1v0417300
Domains
27
LotjaGi2g1v0417300.3
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O64948|LONP2_ARATH Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|G7JYP5|G7JYP5_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi2g1v0417300
Domains
25
LotjaGi2g1v0417300.4
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|G7JYP5|G7JYP5_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi2g1v0417300
Domains
36
LotjaGi4g1v0191600.1
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
36
LotjaGi4g1v0191600.2
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O64948|LONP2_ARATH Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
29
LotjaGi4g1v0191600.3
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
36
LotjaGi4g1v0191600.5
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
36
LotjaGi4g1v0191600.6
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
36
LotjaGi4g1v0191600.7
– Lon protease homolog; TAIR: AT5G47040.1 lon protease 2; Swiss-Prot: sp|O04979|LONP2_SPIOL Lon protease homolog 2, peroxisomal; TrEMBL-Plants: tr|A0A072UQE3|A0A072UQE3_MEDTR Lon protease homolog 2, peroxisomal; Found in the gene: LotjaGi4g1v0191600
Domains
36
LotjaGi5g1v0229900.1
– Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900
Domains
36
LotjaGi5g1v0229900.2
– Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900
Domains
36
LotjaGi5g1v0229900.3
– Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900
Domains
37
LotjaGi5g1v0229900.4
– Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900
Domains
37
LotjaGi5g1v0229900.5
– Lon protease homolog; TAIR: AT5G26860.1 lon protease 1; Swiss-Prot: sp|P93648|LONM_MAIZE Lon protease homolog, mitochondrial; TrEMBL-Plants: tr|A0A0S3SQJ4|A0A0S3SQJ4_PHAAN Lon protease homolog, mitochondrial; Found in the gene: LotjaGi5g1v0229900
Domains
38

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 5.26