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IPR027527 is a Lipoyl synthase, mitochondrial.
<p>Lipoyl synthase is an iron-sulphur protein [[cite:PUB00016125]]. It is localised to mitochondria in yeast and Arabidopsis [[cite:PUB00017446], [cite:PUB00057854]]. It generates lipoic acid, a thiol antioxidant that is linked to a specific Lys as prosthetic group for the pyruvate and alpha-ketoglutarate dehydrogenase complexes and the glycine-cleavage system.</p> <p>This entry represents lipoyl synthase from plant mitochondria.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | ||
| Biological process | Lipoate biosynthetic process | The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. | ||
| Molecular function | Lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. | ||
| Molecular function | 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: lipoyl synthase 2, mitochondrial-like [Glycine max] gi|356543805|ref|XP_003540350.1| | 21 | ||
| – | Lipoyl synthase; TAIR: AT2G20860.1 lipoic acid synthase 1; Swiss-Prot: sp|B7FM45|LIAS_MEDTR Lipoyl synthase, mitochondrial; TrEMBL-Plants: tr|V7BWP4|V7BWP4_PHAVU Lipoyl synthase, mitochondrial; Found in the gene: LotjaGi3g1v0441800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01335 | CDD | 1 | 50.00 |