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IPR027786 is a Nse4/EID family.
<p>Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [[cite:PUB00062983], [cite:PUB00045053], [cite:PUB00062984]]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors [[cite:PUB00062983]].</p> <p>Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals [[cite:PUB00069904]]. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to SMC6 neck and bridges it to the SMC5 head [[cite:PUB00095748]] and to the Nse3 (another SMC5-6 complex subunit) pocket [[cite:PUB00069905]], which seems to increased the stability of the ATP-free SMC5/6 complex.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Cellular component | Smc5-Smc6 complex | A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: non-structural maintenance of chromosome element 4-like [Glycine max] gi|356503478|ref|XP_003520535.1| | 6 | ||
| – | PREDICTED: non-structural maintenance of chromosome element 4-like [Cicer arietinum] gi|502121669|ref|XP_004497405.1| | 6 | ||
| – | PREDICTED: non-structural maintenance of chromosome element 4-like [Cicer arietinum] gi|502121669|ref|XP_004497405.1| | 4 | ||
| – | Non-structural maintenance of chromosome element 4; TAIR: AT1G51130.1 Nse4, component of Smc5/6 DNA repair complex; Swiss-Prot: sp|Q9C689|NSE4A_ARATH Non-structural maintenance of chromosomes element 4 homolog A; TrEMBL-Plants: tr|A0A151TU71|A0A151TU71_CAJCA Non-structural maintenance of chromosome element 4; Found in the gene: LotjaGi1g1v0725800 | 6 | ||
| – | Non-structural maintenance of chromosome element 4; TAIR: AT1G51130.1 Nse4, component of Smc5/6 DNA repair complex; Swiss-Prot: sp|Q9C689|NSE4A_ARATH Non-structural maintenance of chromosomes element 4 homolog A; TrEMBL-Plants: tr|A0A151U864|A0A151U864_CAJCA Non-SMC element 4 isogeny A; Found in the gene: LotjaGi5g1v0364200 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |