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GO:0030915

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Smc5-Smc6 complex
Full defintion A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.
Subterm of

Relationships

The relationship of GO:0030915 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCrb
PMID
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X
Cell Rep. 2016 Jul 12; 16 (2): 368–378.PMID: 27373152

Timely removal of DNA recombination intermediates is critical for genome stability. The DNA helicase-topoisomerase complex, Sgs1-Top3-Rmi1 (STR), is the major pathway for processing these intermediates to generate conservative products. However, the mechanisms that promote STR-mediated functions remain to be defined. Here we show that Sgs1 binds to poly-SUMO chains and associates with the Smc5/6 SUMO E3 complex in yeast. Moreover, these interactions contribute to the sumoylation of Sgs1, Top3, and Rmi1 upon the generation of recombination structures. We show that reduced STR sumoylation leads to accumulation of recombination structures, and impaired growth in conditions when these structures arise frequently, highlighting the importance of STR sumoylation. Mechanistically, sumoylation promotes STR inter-subunit interactions and accumulation at DNA repair centers. These findings expand the roles of sumoylation and Smc5/6 in genome maintenance by demonstrating that they foster STR functions in the removal of recombination intermediates.

Associated Lotus transcripts 22

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0062389.1
– PREDICTED: non-structural maintenance of chromosomes element 1 homolog [Solanum lycopersicum] gi|460365536|ref|XP_004228657.1|
GO terms
2
Lj0g3v0268089.2
– PREDICTED: E3 SUMO-protein ligase MMS21-like [Cicer arietinum] gi|502183399|ref|XP_004517129.1|
GO terms
3
Lj0g3v0268089.3
– PREDICTED: E3 SUMO-protein ligase MMS21-like [Cicer arietinum] gi|502183399|ref|XP_004517129.1|
GO terms
3
Lj1g3v3022480.1
– PREDICTED: non-structural maintenance of chromosomes element 1 homolog [Solanum lycopersicum] gi|460365536|ref|XP_004228657.1|
GO terms
2
Lj1g3v4317580.1
– PREDICTED: non-structural maintenance of chromosome element 4-like [Glycine max] gi|356503478|ref|XP_003520535.1|
GO terms
3
Lj3g3v0824810.2
– PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1|
GO terms
4
Lj3g3v0824810.3
– PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1|
GO terms
4
Lj3g3v0824870.1
– PREDICTED: structural maintenance of chromosomes protein 5-like [Glycine max] gi|356576425|ref|XP_003556332.1|
GO terms
4
Lj3g3v3724440.1
– PREDICTED: structural maintenance of chromosomes protein 6-like [Cicer arietinum] gi|502168978|ref|XP_004514508.1|
GO terms
3
Lj5g3v2300340.1
– PREDICTED: non-structural maintenance of chromosome element 4-like [Cicer arietinum] gi|502121669|ref|XP_004497405.1|
GO terms
3
Lj5g3v2300340.2
– PREDICTED: non-structural maintenance of chromosome element 4-like [Cicer arietinum] gi|502121669|ref|XP_004497405.1|
GO terms
3
LotjaGi1g1v0725800.1
– Non-structural maintenance of chromosome element 4; TAIR: AT1G51130.1 Nse4, component of Smc5/6 DNA repair complex; Swiss-Prot: sp|Q9C689|NSE4A_ARATH Non-structural maintenance of chromosomes element 4 homolog A; TrEMBL-Plants: tr|A0A151TU71|A0A151TU71_CAJCA Non-structural maintenance of chromosome element 4; Found in the gene: LotjaGi1g1v0725800
GO terms
3
LotjaGi3g1v0119400_LC.1
– Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|A0A151TWB4|A0A151TWB4_CAJCA Structural maintenance of chromosomes protein 5; Found in the gene: LotjaGi3g1v0119400_LC
GO terms
4
LotjaGi3g1v0119400_LC.3
– Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|A0A0S3QXY9|A0A0S3QXY9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0119400_LC
GO terms
4
LotjaGi3g1v0119400_LC.4
– Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|G7JE71|G7JE71_MEDTR Structural maintenance-like chromosomes-protein; Found in the gene: LotjaGi3g1v0119400_LC
GO terms
4
LotjaGi3g1v0119500_LC.1
– Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|G7J0X6|G7J0X6_MEDTR Structural maintenance-like chromosomes-protein; Found in the gene: LotjaGi3g1v0119500_LC
GO terms
4
LotjaGi3g1v0119700.1
– Structural maintenance of chromosomes family protein; TAIR: AT5G15920.1 structural maintenance of chromosomes 5; Swiss-Prot: sp|Q9LFS8|SMC5_ARATH Structural maintenance of chromosomes protein 5; TrEMBL-Plants: tr|V7CP68|V7CP68_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0119700
GO terms
4
LotjaGi3g1v0552100.1
– Structural maintenance of chromosomes family protein; TAIR: AT5G07660.1 structural maintenance of chromosomes 6A; Swiss-Prot: sp|Q9FLR5|SMC6A_ARATH Structural maintenance of chromosomes protein 6A; TrEMBL-Plants: tr|A0A0S3SER5|A0A0S3SER5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0552100
GO terms
3
LotjaGi4g1v0065000.1
– SNI1; TAIR: AT4G18470.1 negative regulator of systemic acquired resistance (SNI1); Swiss-Prot: sp|Q9SWA6|SNI1_ARATH Negative regulator of systemic acquired resistance SNI1; TrEMBL-Plants: tr|A0A151TYJ1|A0A151TYJ1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0065000
GO terms
5
LotjaGi4g1v0065000.2
– SNI1; TAIR: AT4G18470.1 negative regulator of systemic acquired resistance (SNI1); Swiss-Prot: sp|Q9SWA6|SNI1_ARATH Negative regulator of systemic acquired resistance SNI1; TrEMBL-Plants: tr|A0A151TYJ1|A0A151TYJ1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0065000
GO terms
5
LotjaGi5g1v0364200.1
– Non-structural maintenance of chromosome element 4; TAIR: AT1G51130.1 Nse4, component of Smc5/6 DNA repair complex; Swiss-Prot: sp|Q9C689|NSE4A_ARATH Non-structural maintenance of chromosomes element 4 homolog A; TrEMBL-Plants: tr|A0A151U864|A0A151U864_CAJCA Non-SMC element 4 isogeny A; Found in the gene: LotjaGi5g1v0364200
GO terms
3
LotjaGi6g1v0191900.1
– Non-structural maintenance of chromosomes element 1 like; TAIR: AT5G21140.1 embryo defective 1379; Swiss-Prot: sp|Q6P881|NSE1_XENTR Non-structural maintenance of chromosomes element 1 homolog; TrEMBL-Plants: tr|I3T4T2|I3T4T2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0191900
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0030915
Cellular component Smc5-Smc6 complex 1 4.55