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IPR030393 is a EngB-type guanine nucleotide-binding (G) domain.
<p>This entry represents the EngB-type G domain.</p> <p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>Within the translation factor-related (TRAFAC) class of P-loop GTPases, the EngB-type is widespread, but not ubiquitous in all three superkingdoms (missing, for example, from the Crenarchaeota, Caenorhabditis, and Drosophila). Proteins of the EngB-type GTPase family are involved in the biogenesis of ribosomes and are essential for the survival of a wide range of bacteria [[cite:PUB00013952], [cite:PUB00031206], [cite:PUB00056964]].</p> <p>The EngB-type GTPase is comprised of a central β-sheet flanked by alpha- helices, in which semi-conserved residues involved in nucleotide binding are located in five motifs, called G1-G5. The G1 region (GxxxxGKS) forms the P-loop that is responsible for binding the phosphate groups of the guanine nucleotide. The G2 region corresponds to the switch I loop, which contains the consensus motif PGxT. The invariant threonine residue is responsible for binding a magnesium ion required for catalysis. The G3 region corresponds to the Walker B motif (DxxG), which forms part of switch II. The G4 (TKxD) and G5 motifs are involved in interactions with the guanine moiety of the substrate [[cite:PUB00031206], [cite:PUB00056964]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA ligase 1-like [Cicer arietinum] gi|502129568|ref|XP_004500348.1| | 13 | ||
| – | PREDICTED: DNA ligase 1-like [Cicer arietinum] gi|502129568|ref|XP_004500348.1| | 16 | ||
| – | PREDICTED: GTP-binding protein At2g22870-like [Glycine max] gi|356507873|ref|XP_003522687.1| | 19 | ||
| – | PREDICTED: GTP-binding protein At2g22870-like [Cicer arietinum] gi|502142648|ref|XP_004505058.1| | 13 | ||
| – | GTP-binding protein; TAIR: AT5G11480.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O81004|Y2287_ARATH GTP-binding protein At2g22870; TrEMBL-Plants: tr|A0A1J7G841|A0A1J7G841_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0399300 | 18 | ||
| – | GTP-binding protein; TAIR: AT2G22870.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O81004|Y2287_ARATH GTP-binding protein At2g22870; TrEMBL-Plants: tr|A0A072UYX7|A0A072UYX7_MEDTR p-loop nucleoside triphosphate hydrolase superfamily protein; Found in the gene: LotjaGi4g1v0056500 | 19 | ||
| – | P-loop containing nucleoside triphosphate hydrolases superfamily protein; TAIR: AT5G58370.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q1GJX8|ENGB_RUEST Probable GTP-binding protein EngB; TrEMBL-Plants: tr|A0A151UA06|A0A151UA06_CAJCA Putative GTP-binding protein engB; Found in the gene: LotjaGi6g1v0104400 | 15 | ||
| – | P-loop containing nucleoside triphosphate hydrolases superfamily protein; TAIR: AT5G58370.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q1GJX8|ENGB_RUEST Probable GTP-binding protein EngB; TrEMBL-Plants: tr|A0A151UA06|A0A151UA06_CAJCA Putative GTP-binding protein engB; Found in the gene: LotjaGi6g1v0104400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |