Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR030564 is a Myotubularin.
<p>The myotubularin family constitutes a large group of conserved proteins, with 14 members in humans consisting of myotubularin (MTM1) and 13 myotubularin-related proteins (MTMR1-MTMR13). Orthologues have been found throughout the eukaryotic kingdom, but not in bacteria. MTM1 dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) to phosphatidylinositol and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] to phosphatidylinositol 5-monophosphate (PI5P) [[cite:PUB00073208], [cite:PUB00073209], [[cite:PUB00154955]]. The substrate phosphoinositides (PIs) are known to regulate traffic within the endosomal-lysosomal pathway [[cite:PUB00043723]]. MTMR1, MTMR2, MTMR3, MTMR4, and MTMR6 have also been shown to utilise PI(3)P as a substrate, suggesting that this activity is intrinsic to all active family members. On the other hand, six of the MTM family members encode for catalytically inactive phosphatases. Inactive myotubularin phosphatases contain substitutions in the Cys and Arg residues of the Cys-X5-Arg motif. MTM pseudophosphatases have been found to interact with MTM catalytic phosphatases [[cite:PUB00073211]]. The myotubularin family includes several members mutated in neuromuscular diseases or associated with metabolic syndrome, obesity, and cancer [[cite:PUB00073206]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: myotubularin-related protein 2-like [Cicer arietinum] gi|502118244|ref|XP_004496171.1| | 9 | ||
| – | PREDICTED: myotubularin-related protein 2-like [Glycine max] gi|356574661|ref|XP_003555464.1| | 10 | ||
| – | Myotubularin; TAIR: AT3G10550.1 Myotubularin-like phosphatases II superfamily; Swiss-Prot: sp|F4J3T8|MYTM1_ARATH Phosphatidylinositol-3-phosphatase myotubularin-1; TrEMBL-Plants: tr|V7BH90|V7BH90_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0157200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |