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IPR004182

Description

IPR004182 is a GRAM domain.

<p>The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. It is normally about 70 amino acids in length. It is thought to be an intracellular protein-binding or lipid-binding signalling domain, which has an important function in membrane-associated processes. The structure of the GRAM domain is similar to that found in PH domains [[cite:PUB00019649]]. Mutations in the GRAM domain of myotubularins cause a muscle disease, which suggests that the domain is essential for the full function of the enzyme [[cite:PUB00019649]]. Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids [[cite:PUB00022130]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 37

Transcript Name Description Predicted domains Domain count
GLABRA2 expression modulator [Medicago truncatula] gi|357465343|ref|XP_003602953.1| 7
5
PREDICTED: GLABRA2 expression modulator-like [Glycine max] gi|356566022|ref|XP_003551234.1| 6
GEM-like protein [Medicago truncatula] gi|357499751|ref|XP_003620164.1| 5
GEM-like protein [Medicago truncatula] gi|357508343|ref|XP_003624460.1| 7
PREDICTED: C2 and GRAM domain-containing protein At1g03370-like [Cicer arietinum] gi|502142930|ref|XP_004505156.1| 18
GEM-like protein [Medicago truncatula] gi|357508343|ref|XP_003624460.1| 7
PREDICTED: GEM-like protein 4-like [Cicer arietinum] gi|502171563|ref|XP_004515060.1| 6
PREDICTED: myotubularin-related protein 2-like [Cicer arietinum] gi|502118244|ref|XP_004496171.1| 9
PREDICTED: GEM-like protein 4-like [Cicer arietinum] gi|502121267|ref|XP_004497247.1| 7
PREDICTED: GEM-like protein 4-like [Cicer arietinum] gi|502121267|ref|XP_004497247.1| 7
PREDICTED: GEM-like protein 4-like [Cicer arietinum] gi|502121267|ref|XP_004497247.1| 5
PREDICTED: GEM-like protein 4-like [Glycine max] gi|356536453|ref|XP_003536752.1| 5
PREDICTED: C2 and GRAM domain-containing protein At1g03370-like [Glycine max] gi|356532855|ref|XP_003534985.1| 19
C2 and GRAM domain-containing protein; TAIR: AT5G50170.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9FGS8|C2GR2_ARATH C2 and GRAM domain-containing protein At5g50170; TrEMBL-Plants: tr|A0A0R0K9Z2|A0A0R0K9Z2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0196800 21
C2 and GRAM domain-containing protein; TAIR: AT5G50170.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9FGS8|C2GR2_ARATH C2 and GRAM domain-containing protein At5g50170; TrEMBL-Plants: tr|A0A0R0K9Z2|A0A0R0K9Z2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0196800 21
GEM-like protein 1; TAIR: AT1G28200.1 FH interacting protein 1; Swiss-Prot: sp|Q9SE96|GEML1_ARATH GEM-like protein 1; TrEMBL-Plants: tr|A0A0L9UGE2|A0A0L9UGE2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0349700 10
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G13200.1 GRAM domain family protein; Swiss-Prot: sp|Q9LYV6|GEML5_ARATH GEM-like protein 5; TrEMBL-Plants: tr|I3TA12|I3TA12_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0631000 10
Myotubularin; TAIR: AT3G10550.1 Myotubularin-like phosphatases II superfamily; Swiss-Prot: sp|F4J3T8|MYTM1_ARATH Phosphatidylinositol-3-phosphatase myotubularin-1; TrEMBL-Plants: tr|V7BH90|V7BH90_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0157200 18
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G23370.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FMW4|GEML8_ARATH Putative GEM-like protein 8; TrEMBL-Plants: tr|G7KKC8|G7KKC8_MEDTR GRAM domain protein/ABA-responsive-like protein; Found in the gene: LotjaGi2g1v0178700 9
GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TWG7|A0A072TWG7_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 16
GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TJX9|A0A072TJX9_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 16
GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TJX9|A0A072TJX9_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 16
GRAM domain family protein; TAIR: AT1G02120.1 GRAM domain family protein; Swiss-Prot: sp|F4HVW5|VAD1_ARATH Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; TrEMBL-Plants: tr|A0A072TWG7|A0A072TWG7_MEDTR PH-GRAM1-TCB1D9-TCB1D9B domain protein; Found in the gene: LotjaGi3g1v0067300 16
C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|I1KNM4|I1KNM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0005000 24
C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|I1KNM4|I1KNM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0005000 24
C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K882|K7K882_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 28
C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K881|K7K881_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 20
C2 domain-containing protein / GRAM domain-containing protein; TAIR: AT3G59660.1 C2 domain-containing protein / GRAM domain-containing protein; Swiss-Prot: sp|Q8W4D4|BAGP1_ARATH BAG-associated GRAM protein 1; TrEMBL-Plants: tr|K7K882|K7K882_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0068800 20
GRAM domain protein/ABA-responsive-like protein; TAIR: AT2G22475.1 GRAM domain family protein; Swiss-Prot: sp|Q8S8F8|GEM_ARATH GLABRA2 expression modulator; TrEMBL-Plants: tr|A0A0B2QS05|A0A0B2QS05_GLYSO GLABRA2 expression modulator; Found in the gene: LotjaGi4g1v0159300 10
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G08350.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FTA0|GEML4_ARATH GEM-like protein 4; TrEMBL-Plants: tr|I3SIE9|I3SIE9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0438500 9
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G08350.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FTA0|GEML4_ARATH GEM-like protein 4; TrEMBL-Plants: tr|B7FJD2|B7FJD2_MEDTR GRAM domain protein/ABA-responsive-like protein; Found in the gene: LotjaGi5g1v0353600 8
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G08350.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FTA0|GEML4_ARATH GEM-like protein 4; TrEMBL-Plants: tr|B7FJD2|B7FJD2_MEDTR GRAM domain protein/ABA-responsive-like protein; Found in the gene: LotjaGi5g1v0353600 8
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G23370.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FMW4|GEML8_ARATH Putative GEM-like protein 8; TrEMBL-Plants: tr|A0A072W2G8|A0A072W2G8_MEDTR GRAM domain protein/ABA-responsive-like protein; Found in the gene: LotjaGi5g1v0353700 8
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G08350.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FTA0|GEML4_ARATH GEM-like protein 4; TrEMBL-Plants: tr|K7LM06|K7LM06_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0353700 8
GRAM domain protein/ABA-responsive-like protein; TAIR: AT5G08350.1 GRAM domain-containing protein / ABA-responsive protein-like protein; Swiss-Prot: sp|Q9FTA0|GEML4_ARATH GEM-like protein 4; TrEMBL-Plants: tr|K7LM06|K7LM06_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0353700 8
C2 and GRAM domain-containing protein; TAIR: AT1G03370.1 C2 calcium/lipid-binding and GRAM domain containing protein; Swiss-Prot: sp|Q9ZVT9|C2GR1_ARATH C2 and GRAM domain-containing protein At1g03370; TrEMBL-Plants: tr|A0A0B2S6D4|A0A0B2S6D4_GLYSO C2 and GRAM domain-containing protein; Found in the gene: LotjaGi6g1v0281500 24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.70