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IPR031925

Source: InterPro

Description

IPR031925 is a Tubulin-specific chaperone C, N-terminal.

<p>Tubulin binding cofactor C (TBCC) is a post-chaperonin involved in folding pathways that lead to the final release of alpha beta native heterodimers incorporated in microtubules. TBCC is organised into three different domains: N-terminal, CARP and C-terminal [[cite:PUB00076132]].</p> <p>This entry represents the N-terminal domain of TBCC. The N-terminal comprises a structured coiled coil and a highly dynamic N-terminal region which concentrates 80% of charged and polar residues and is believed to be important in interaction with tubulin [[cite:PUB00076132]]. Overall, the N-terminal domain of TBCC is responsible for its interaction with components of the centrosome by its N-terminal domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0015631
Molecular function Tubulin binding Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v0528580.1
– PREDICTED: tubulin-folding cofactor C-like [Cicer arietinum] gi|502140152|ref|XP_004504081.1|
Domains
14
LotjaGi4g1v0396500.1
– Tubulin folding cofactor C, putative; TAIR: AT4G39920.1 C-CAP/cofactor C-like domain-containing protein; Swiss-Prot: sp|Q9SMR2|TBCC_ARATH Tubulin-folding cofactor C; TrEMBL-Plants: tr|A0A072TTR3|A0A072TTR3_MEDTR Tubulin folding cofactor C, putative; Found in the gene: LotjaGi4g1v0396500
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00