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IPR032171

Source: InterPro

Description

IPR032171 is a C-terminal of Roc, COR-A domain.

<p>This entry corresponds to COR-A, located at the N-terminal of COR. It interacts with the Roc domain stabilising the GTPase activity of LRRK2 [[cite:PUB00160124]]. COR-A consists of multiple alpha-helices and a short three-stranded antiparallel sheet [[cite:PUB00160125]].</p> <p>The C-terminal of Roc domain, COR, along with Roc functions as the putative regulator of kinase activity. It functions as a proper GTP-binding protein with a low GTPase activity somehow stimulating the kinase activity [[cite:PUB00051458]]. COR is divided in two subdomains: COR-A and COR-B. The Roc-COR tandem is found in Roco-containing proteins from bacterias and eukaryotes. Its most prominent member is the leucine-rich repeat kinase 2 LRRK2 [[cite:PUB00050311]]. It also contains Leucine-rich repeat kinase 1 LRKK1, Death-associated protein kinase 1 DAPK1 and Malignant fibrous histiocytoma amplified sequence 1 MFHAS1 [[cite:PUB00124639], [cite:PUB00160280]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj6g3v0802310.1
– Nucleotide-binding oligomerization domain-containing protein [Medicago truncatula] gi|357459937|ref|XP_003600250.1|
Domains
18
LotjaGi6g1v0149700.1
– Tornado 1; TAIR: AT5G55540.1 tornado 1; Swiss-Prot: sp|Q9FJ57|TRN1_ARATH Protein TORNADO 1; TrEMBL-Plants: tr|A0A0B2SG74|A0A0B2SG74_GLYSO Protein NLRC3; Found in the gene: LotjaGi6g1v0149700
Domains
17
LotjaGi6g1v0149700.2
– Tornado 1; TAIR: AT5G55540.1 tornado 1; Swiss-Prot: sp|Q9FJ57|TRN1_ARATH Protein TORNADO 1; TrEMBL-Plants: tr|I1KYG3|I1KYG3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0149700
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 33.33