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IPR032263 is a ATP-citrate synthase, citrate-binding domain.
<p>This is a conserved domain containing the citrate-binding sites found in the ATP-citrate synthases (also known as ATP citrate lyases). This domain has a Rossmann fold [[cite:PUB00065389]].</p> <p>The ATP-citrate synthase family is responsible for the synthesis of cytosolic acetyl-CoA, a crucial substrate for de novo lipid synthesis, including cholesterol and fatty acids. In animals, these enzymes typically have a homomeric structure, whereas in plants, they are composed of distinct alpha and beta chains. These proteins play a central role in lipid metabolism, contributing to the elongation of fatty acids and the biosynthesis of various compounds such as isoprenoids and flavonoids. They are characterised by its membership in the succinate/malate CoA ligase subunit families, with distinct N-terminal and C-terminal sections.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ATP-citrate synthase alpha chain protein 1-like [Glycine max] gi|356501618|ref|XP_003519621.1| | 11 | ||
| – | PREDICTED: ATP-citrate synthase alpha chain protein 2-like [Glycine max] gi|356505743|ref|XP_003521649.1| | 11 | ||
| – | PREDICTED: ATP-citrate synthase alpha chain protein 1-like [Glycine max] gi|356501618|ref|XP_003519621.1| | 11 | ||
| – | PREDICTED: ATP-citrate synthase alpha chain protein 1-like [Glycine max] gi|356501618|ref|XP_003519621.1| | 6 | ||
| – | PREDICTED: ATP-citrate synthase alpha chain protein 1-like [Glycine max] gi|356525708|ref|XP_003531465.1| | 12 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G09430.1 ATP-citrate lyase A-3; Swiss-Prot: sp|Q2QZ86|ACLA2_ORYSJ ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|I1JR24|I1JR24_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750300 | 13 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G09430.1 ATP-citrate lyase A-3; Swiss-Prot: sp|Q2QZ86|ACLA2_ORYSJ ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|I1JR24|I1JR24_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750300 | 13 | ||
| – | ATP-citrate synthase; TAIR: AT1G09430.1 ATP-citrate lyase A-3; Swiss-Prot: sp|Q2QNG7|ACLA3_ORYSJ ATP-citrate synthase alpha chain protein 3; TrEMBL-Plants: tr|A0A151TX29|A0A151TX29_CAJCA ATP-citrate synthase; Found in the gene: LotjaGi1g1v0750300 | 7 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G10670.1 ATP-citrate lyase A-1; Swiss-Prot: sp|Q9SGY2|ACLA1_ARATH ATP-citrate synthase alpha chain protein 1; TrEMBL-Plants: tr|I1JC43|I1JC43_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0322000 | 13 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G60810.1 ATP-citrate lyase A-2; Swiss-Prot: sp|O22718|ACLA2_ARATH ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|G7K076|G7K076_MEDTR ATP-citrate synthase alpha chain protein; Found in the gene: LotjaGi2g1v0322000 | 12 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G60810.1 ATP-citrate lyase A-2; Swiss-Prot: sp|O22718|ACLA2_ARATH ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|A0A151RQ09|A0A151RQ09_CAJCA ATP-citrate synthase; Found in the gene: LotjaGi3g1v0130800 | 13 | ||
| – | ATP-citrate synthase; TAIR: AT1G10670.1 ATP-citrate lyase A-1; Swiss-Prot: sp|Q9SGY2|ACLA1_ARATH ATP-citrate synthase alpha chain protein 1; TrEMBL-Plants: tr|K7L723|K7L723_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130800 | 7 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G60810.1 ATP-citrate lyase A-2; Swiss-Prot: sp|O22718|ACLA2_ARATH ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|A0A151RQ09|A0A151RQ09_CAJCA ATP-citrate synthase; Found in the gene: LotjaGi3g1v0130800 | 13 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G60810.1 ATP-citrate lyase A-2; Swiss-Prot: sp|O22718|ACLA2_ARATH ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|A0A151RQ09|A0A151RQ09_CAJCA ATP-citrate synthase; Found in the gene: LotjaGi3g1v0130800 | 13 | ||
| – | Succinate--CoA ligase [ADP]-forming] subunit beta; TAIR: AT1G60810.1 ATP-citrate lyase A-2; Swiss-Prot: sp|O22718|ACLA2_ARATH ATP-citrate synthase alpha chain protein 2; TrEMBL-Plants: tr|K7L723|K7L723_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0130800 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56059 | SUPERFAMILY | 1 | 6.67 |