Description

IPR033140 is a Lipase, GDXG, putative serine active site.

<p>The following lipolytic enzymes are evolutionarily related:</p> <ul> <li>Mammalian hormone sensitive lipase (HSL). In adipose tissue and heart, HSL primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.</li> <li>Mammalian arylacetamide deacetylase (DAC).</li> <li>Moraxella strain TA144 lipase 2 (gene lip2), an enzyme active at a low temperature.</li> <li>Acinetobacter calcoaceticus esterase which seems to be active on simple triglycerides such as triacetin.</li> <li>Streptomyces hygroscopicus acetyl-hydrolase (gene bah), which removes the N-acetyl group from the antibiotic bialaphos.</li> <li>Escherichia coli acetyl esterase.</li> </ul> <p>These enzymes contain a Ser-centred consensus sequence and a conserved His-Gly dipeptide found in most lipase N-terminal domains. These sequences are involved in the lipase active site conformation since substitution of the conserved Ser or His residues by Ala and Gln, respectively, results in the loss of both lipase and esterase activities [[cite:PUB00001111]].</p> <p>This entry represents a conserved region containing the putative Ser active site.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: