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IPR033308 is a PGAP5/Cdc1/Ted1.
<p>This entry includes mammalian PGAP5 protein (also known as MPPE1) and budding yeast Ted1 and Cdc1 proteins. PGAP5 is involved in transport of GPI-anchored proteins from the ER to the Golgi [[cite:PUB00078391]]. Ted1 is a GPI-glycan remodelase that acts together with Emp24 and Erv25 in cargo exit from the endoplasmic reticulum [[cite:PUB00078388], [cite:PUB00078389]]. Ted1 functions as the yeast orthologue of mammalian PGAP5 by removing a specific EtNP on GPI-glycan. By contrast, the other yeast PGAP5 homologue, Cdc1, seems not to be involved in GPI-AP trafficking [[cite:PUB00078388]]. Instead, removes specifically the side-chain EtNP placed at the first mannose of the GPI-glycan, which is not important for trafficking but facilitates the integration of GPI-APs into the yeast cell wall [[cite:PUB00078390]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Serine/threonine phosphatase-like protein [Medicago truncatula] gi|357514393|ref|XP_003627485.1| | 14 | ||
| – | Metallophosphoesterase [Medicago truncatula] gi|357513939|ref|XP_003627258.1| | 17 | ||
| – | PREDICTED: metallophosphoesterase 1-like [Fragaria vesca subsp]. vesca] gi|470127340|ref|XP_004299630.1| | 9 | ||
| – | Serine/threonine-protein phosphatase; TAIR: AT1G53710.1 Calcineurin-like metallo-phosphoesterase superfamily protein; Swiss-Prot: sp|Q9UUH0|YKIC_SCHPO Uncharacterized protein C630.12; TrEMBL-Plants: tr|A0A0B2NWF3|A0A0B2NWF3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi3g1v0406400 | 15 | ||
| – | Calcineurin-like metallo-phosphoesterase superfamily protein, putative isoform 1; TAIR: AT1G53710.2 Calcineurin-like metallo-phosphoesterase superfamily protein; Swiss-Prot: sp|Q566Y9|MPPE1_DANRE Metallophosphoesterase 1; TrEMBL-Plants: tr|A0A1J7GWH2|A0A1J7GWH2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0415700 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 20.00 |