Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR033704 is a dUTPase, trimeric.
<p>Trimeric dUTP diphosphatases (dUTP nucleotidohydrolases or dUTPases), are the most common family of dUTPase, found in bacteria, eukaryotes, and archaea. They catalyze the hydrolysis of the dUTP-Mg complex (dUTP-Mg) into dUMP and pyrophosphate. This reaction is crucial for the preservation of chromosomal integrity as it removes dUTP and therefore reduces the cellular dUTP/dTTP ratio, and prevents dUTP from being incorporated into DNA. It also provides dUMP as the precursor for dTTP synthesis via the thymidylate synthase pathway. dUTPases are homotrimeric, except some monomeric viral dUTPases, which have been shown to mimic a trimer. Active sites are located at the subunit interface [[cite:PUB00080097], [cite:PUB00004115]].</p> <p>This entry represents the main structural domain, which folds into an eight-stranded jelly-roll β barrel.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase-like [Glycine max] gi|356553208|ref|XP_003544950.1| | 12 | ||
| – | PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase-like [Glycine max] gi|356569953|ref|XP_003553158.1| | 10 | ||
| – | Deoxyuridine 5'-triphosphate nucleotidohydrolase; TAIR: AT3G46940.2 DUTP-PYROPHOSPHATASE-LIKE 1; Swiss-Prot: sp|P32518|DUT_SOLLC Deoxyuridine 5'-triphosphate nucleotidohydrolase; TrEMBL-Plants: tr|V7BAU1|V7BAU1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0218800 | 12 | ||
| – | Deoxyuridine 5'-triphosphate nucleotidohydrolase; TAIR: AT3G46940.2 DUTP-PYROPHOSPHATASE-LIKE 1; Swiss-Prot: sp|P32518|DUT_SOLLC Deoxyuridine 5'-triphosphate nucleotidohydrolase; TrEMBL-Plants: tr|V7BAU1|V7BAU1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0218800 | 12 | ||
| – | Deoxyuridine 5'-triphosphate nucleotidohydrolase; TAIR: AT3G46940.2 DUTP-PYROPHOSPHATASE-LIKE 1; Swiss-Prot: sp|P32518|DUT_SOLLC Deoxyuridine 5'-triphosphate nucleotidohydrolase; TrEMBL-Plants: tr|K7MPZ4|K7MPZ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0047200 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07557 | CDD | 1 | 20.00 |