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IPR033811 is a Proteasome beta 3 subunit.
<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that seems to be involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes the proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Most proteasome subunits can be classified, on the basis on sequence similarities into two groups, alpha (A) and beta (B). These are arranged in four rings of seven proteins, consisting of a ring of alpha subunits, two rings of beta subunits, and a ring of alpha subunits. In eukaryotes, each alpha and each beta ring consists of different proteins. Three of the beta subunits are peptidases in subfamily T1A, and each has a distinctive specificity (trypsin-like, chymotrypsin-like and glutamyl peptidase-like). The peptidases are N-terminal nucleophile hydrolases in which the N-terminal threonine is the nucleophile in the hydrolytic reaction [[cite:PUB00030848]]. In the immunoproteasome, the catalytic components are replaced by three specialist, catalytic beta subunits [[cite:PUB00065662]]. In bacteria and archaea there is only one alpha subunit and one beta subunit, and each ring is a homoseptamer.</p> <p>The entry represents the proteasome beta type-3 subunit (MEROPS identifier T01.983), which is not one of the proteolytic subunits.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proteasome core complex, beta-subunit complex | The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. | ||
| Biological process | Proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9LST7|PSB3_ORYSJ Proteasome subunit beta type-3; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 | ||
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 | ||
| – | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03759 | CDD | 1 | 16.67 |