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IPR016050 is a Proteasome beta-type subunit, conserved site.
<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that seems to be involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes the proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Most proteasome subunits can be classified, on the basis on sequence similarities into two groups, alpha (A) and beta (B). These are arranged in four rings of seven proteins, consisting of a ring of alpha subunits, two rings of beta subunits, and a ring of alpha subunits. In eukaryotes, each alpha and each beta ring consists of different proteins. Three of the beta subunits are peptidases in subfamily T1A, and each has a distinctive specificity (trypsin-like, chymotrypsin-like and glutamyl peptidase-like). The peptidases are N-terminal nucleophile hydrolases in which the N-terminal threonine is the nucleophile in the hydrolytic reaction [[cite:PUB00030848]]. In the immunoproteasome, the catalytic components are replaced by three specialist, catalytic beta subunits [[cite:PUB00065662]]. In bacteria and archaea there is only one alpha subunit and one beta subunit, and each ring is a homoseptamer.</p> <p>This entry represents a conserved sequence region found in the N-terminal region of these proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. | ||
Cellular component | Proteasome core complex | A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. | ||
Biological process | Proteolysis involved in cellular protein catabolic process | The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Os06g0643100 [Oryza sativa Japonica Group] gi|115469154|ref|NP_001058176.1| | 9 | ||
– | PREDICTED: proteasome subunit beta type-5-like [Glycine max] gi|356516569|ref|XP_003526966.1| | 14 | ||
– | Proteasome subunit beta type [Medicago truncatula] gi|357500389|ref|XP_003620483.1| | 9 | ||
– | PREDICTED: proteasome subunit beta type-2-A-like [Cicer arietinum] gi|502159086|ref|XP_004511389.1| | 12 | ||
– | PREDICTED: proteasome subunit beta type-6-like [Cicer arietinum] gi|502132065|ref|XP_004501214.1| | 14 | ||
– | PREDICTED: proteasome subunit beta type-6-like [Glycine max] gi|356507848|ref|XP_003522675.1| | 14 | ||
– | PREDICTED: proteasome subunit beta type-3-A-like [Cicer arietinum] gi|502107572|ref|XP_004493306.1| | 9 | ||
– | PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| | 14 | ||
– | PREDICTED: proteasome subunit beta type-4-like [Cicer arietinum] gi|502113510|ref|XP_004494673.1| | 14 | ||
– | PREDICTED: proteasome subunit beta type-1-like [Glycine max] gi|356526807|ref|XP_003532008.1| | 12 | ||
– | Proteasome subunit beta type [Medicago truncatula] gi|357504055|ref|XP_003622316.1| | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9LST7|PSB3_ORYSJ Proteasome subunit beta type-3; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3S150|I3S150_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0157600 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT3G26340.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|O24361|PSB5_SPIOL Proteasome subunit beta type-5; TrEMBL-Plants: tr|I3T0L3|I3T0L3_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0237700 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT3G26340.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|O24361|PSB5_SPIOL Proteasome subunit beta type-5; TrEMBL-Plants: tr|I3T0L3|I3T0L3_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0237700 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT4G31300.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|Q8LD27|PSB6_ARATH Proteasome subunit beta type-6; TrEMBL-Plants: tr|I3SPC4|I3SPC4_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0397200 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT1G21720.1 proteasome beta subunit C1; Swiss-Prot: sp|Q9XI05|PSB3A_ARATH Proteasome subunit beta type-3-A; TrEMBL-Plants: tr|I3T8P9|I3T8P9_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0656000 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|A0A0S3S5A0|A0A0S3S5A0_PHAAN Proteasome subunit beta type; Found in the gene: LotjaGi1g1v0778500 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT5G40580.1 20S proteasome beta subunit PBB2; Swiss-Prot: sp|Q7DLS1|PSB7B_ARATH Proteasome subunit beta type-7-B; TrEMBL-Plants: tr|I3STF0|I3STF0_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0125900 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT5G40580.1 20S proteasome beta subunit PBB2; Swiss-Prot: sp|Q7DLS1|PSB7B_ARATH Proteasome subunit beta type-7-B; TrEMBL-Plants: tr|I3STF0|I3STF0_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0125900 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT5G40580.1 20S proteasome beta subunit PBB2; Swiss-Prot: sp|Q7DLS1|PSB7B_ARATH Proteasome subunit beta type-7-B; TrEMBL-Plants: tr|I3STF0|I3STF0_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0125900 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT1G56450.1 20S proteasome beta subunit G1; Swiss-Prot: sp|Q7DLR9|PSB4_ARATH Proteasome subunit beta type-4; TrEMBL-Plants: tr|I1NC65|I1NC65_SOYBN Proteasome subunit beta type; Found in the gene: LotjaGi2g1v0362800 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT3G22630.1 20S proteasome beta subunit D1; Swiss-Prot: sp|O23714|PSB2A_ARATH Proteasome subunit beta type-2-A; TrEMBL-Plants: tr|C6SW24|C6SW24_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0452800 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT3G60820.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; Swiss-Prot: sp|O82531|PSB1_PETHY Proteasome subunit beta type-1; TrEMBL-Plants: tr|I3SL66|I3SL66_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi3g1v0433000 | 13 | ||
– | Proteasome subunit beta type; TAIR: AT5G40580.1 20S proteasome beta subunit PBB2; Swiss-Prot: sp|Q7DLS1|PSB7B_ARATH Proteasome subunit beta type-7-B; TrEMBL-Plants: tr|I3STF0|I3STF0_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi5g1v0246600 | 14 | ||
– | Proteasome subunit beta type; TAIR: AT5G40580.1 20S proteasome beta subunit PBB2; Swiss-Prot: sp|Q7DLS1|PSB7B_ARATH Proteasome subunit beta type-7-B; TrEMBL-Plants: tr|I3STF0|I3STF0_LOTJA Proteasome subunit beta type; Found in the gene: LotjaGi5g1v0246600 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd03763 | CDD | 1 | 3.45 |