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IPR033812 is a Proteasome subunit alpha5.
<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of α/β/β/α subunits. There are seven different alpha subunits and seven different beta subunits [[cite:PUB00030848]]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [[cite:PUB00080992]]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.</p> <p>This entry represents the proteasome alpha 5 subunit (MEROPS identifier T01.975) also known as Pup2.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proteasome core complex, alpha-subunit complex | The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. | ||
| Biological process | Proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 20S proteasome alpha subunit E2 isoform 2 [Theobroma cacao] gi|508780133|gb|EOY27389.1| | 15 | ||
| – | Proteasome subunit alpha type; TAIR: AT3G14290.1 20S proteasome alpha subunit E2; Swiss-Prot: sp|Q9LSU1|PSA5_ORYSJ Proteasome subunit alpha type-5; TrEMBL-Plants: tr|I3S0W6|I3S0W6_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0345600 | 15 | ||
| – | Proteasome subunit alpha type; TAIR: AT3G14290.1 20S proteasome alpha subunit E2; Swiss-Prot: sp|Q9LSU1|PSA5_ORYSJ Proteasome subunit alpha type-5; TrEMBL-Plants: tr|I3S0W6|I3S0W6_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi5g1v0345600 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03753 | CDD | 1 | 33.33 |