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IPR033890

Source: InterPro

Description

IPR033890 is a GDP-mannose 3,5-epimerase.

<p>This subgroup of NDP-sugar epimerase/dehydratases are extended short-chain dehydrogenase/reductases (SDRs); they have the characteristic active site tetrad, and an NAD-binding motif: TGXXGXX[AG], which is a close match to the canonical NAD-binding motif. Members include Arabidopsis thaliana GDP-mannose-3',5'-epimerase which catalyzes the epimerization of GDP-alpha-D-mannose to form GDP-beta-L-galactose [[cite:PUB00039891]]. It also catalyses an epimerization reaction that releases GDP-L-gulose, an intermediate that could be dedicated for the de novo biosynthesis of vitamin C in plants [[cite:PUB00081620]].</p> <p>Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (α/β folding pattern with a central β-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids [[cite:PUB00000419], [cite:PUB00081093], [cite:PUB00027780], [cite:PUB00027779]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0047918
Molecular function GDP-mannose 3,5-epimerase activity Catalysis of the reaction: GDP-mannose = GDP-L-galactose.
Subterm of
GO:0051287
Molecular function NAD binding Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj0g3v0283729.1
– PREDICTED: GDP-mannose 3,5-epimerase-like isoform X1 [Cicer arietinum] gi|502117369|ref|XP_004495797.1|
Domains
10
Lj0g3v0283729.6
– PREDICTED: GDP-mannose 3,5-epimerase-like [Glycine max] gi|356576698|ref|XP_003556467.1|
Domains
10
Lj1g3v4979970.1
– PREDICTED: GDP-mannose 3,5-epimerase-like isoform X1 [Cicer arietinum] gi|502117369|ref|XP_004495797.1|
Domains
10
LotjaGi1g1v0780800.1
– GDP-mannose-3',5'-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A0L9VKP5|A0A0L9VKP5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0780800
Domains
10
LotjaGi1g1v0780800.2
– GDP-mannose-3',5'-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A0L9VKP5|A0A0L9VKP5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0780800
Domains
10
LotjaGi1g1v0780800.3
– GDP-mannose-3',5'-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A0L9VKP5|A0A0L9VKP5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0780800
Domains
10
LotjaGi5g1v0213200.1
– GDP-mannose 3,5-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A151U593|A0A151U593_CAJCA GDP-mannose 3,5-epimerase; Found in the gene: LotjaGi5g1v0213200
Domains
10
LotjaGi5g1v0213200.2
– GDP-mannose 3,5-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A151U593|A0A151U593_CAJCA GDP-mannose 3,5-epimerase; Found in the gene: LotjaGi5g1v0213200
Domains
10
LotjaGi5g1v0213200.3
– GDP-mannose 3,5-epimerase; TAIR: AT5G28840.1 GDP-D-mannose 3',5'-epimerase; Swiss-Prot: sp|A3C4S4|GME1_ORYSJ GDP-mannose 3,5-epimerase 1; TrEMBL-Plants: tr|A0A151U593|A0A151U593_CAJCA GDP-mannose 3,5-epimerase; Found in the gene: LotjaGi5g1v0213200
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05273 CDD 1 11.11