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IPR033917 is a ML domain, phosphatidylinositol/phosphatidylglycerol transfer protein.
<p>The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like β-sandwich fold similar to that of E-set Ig domains. This domain is present in proteins from plants, animals and fungi, including the following proteins: <ul> <li>Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein -Npc2), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes [[cite:PUB00029036]].</li> <li>House-dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus [[cite:PUB00032538]].</li> </ul> </p> <p>This entry refers to the ML domain found in phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP). PG/PI-TP has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure [[cite:PUB00081735]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Intracellular sterol transport | The directed movement of sterols within cells. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphatidylglycerol/phosphatidylinositol transfer protein-like [Glycine max] gi|356542064|ref|XP_003539491.1| | 18 | ||
| – | PREDICTED: phosphatidylglycerol/phosphatidylinositol transfer protein-like [Glycine max] gi|356542064|ref|XP_003539491.1| | 18 | ||
| – | Phosphatidylglycerol/phosphatidylinositol transfer protein; TAIR: AT3G11780.1 MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; Swiss-Prot: sp|Q54SW1|Y2179_DICDI Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179; TrEMBL-Plants: tr|C6TFA8|C6TFA8_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0184400 | 18 | ||
| – | MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; TAIR: AT3G44100.1 MD-2-related lipid recognition domain-containing protein; Swiss-Prot: sp|D4AYQ6|NPC2_ARTBC Phosphatidylglycerol/phosphatidylinositol transfer protein; TrEMBL-Plants: tr|I3SA64|I3SA64_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0470600 | 18 | ||
| – | MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; TAIR: AT3G11780.1 MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; Swiss-Prot: sp|Q54SW1|Y2179_DICDI Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179; TrEMBL-Plants: tr|I3T0S6|I3T0S6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0107000 | 18 | ||
| – | MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; TAIR: AT3G11780.1 MD-2-related lipid recognition domain-containing protein / ML domain-containing protein; Swiss-Prot: sp|Q54SW1|Y2179_DICDI Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179; TrEMBL-Plants: tr|I3SG86|I3SG86_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0107000 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00917 | CDD | 1 | 16.67 |