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IPR034642 is a Proteasome subunit alpha6.
<p>The proteasome (or macropain) ([ec:3.4.25.1]) [[cite:PUB00000524], [cite:PUB00000148], [cite:PUB00004123], [cite:PUB00001329], [cite:PUB00005460]] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of α/β/β/α subunits. There are seven different alpha subunits and seven different beta subunits [[cite:PUB00030848]]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [[cite:PUB00080992]]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.</p> <p>This entry includes the non-proteolytic alpha6 subunit of the 19S proteasome (MEROPS identifier T01.971). The equivalent subunit in Saccharomyces cerevisiae is known as alpha1. A single nuclear polymorphism is associated with a higher risk of myocardial infarction in a Japanese population, possibly because of an increased risk of atherosclerosis [[cite:PUB00083828]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proteasome core complex, alpha-subunit complex | The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Proteasome subunit alpha type; TAIR: AT5G35590.1 proteasome alpha subunit A1; Swiss-Prot: sp|O48551|PSA6_SOYBN Proteasome subunit alpha type-6; TrEMBL-Plants: tr|I3T518|I3T518_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0323300 | 15 | ||
| – | Proteasome subunit alpha type; TAIR: AT5G35590.1 proteasome alpha subunit A1; Swiss-Prot: sp|O48551|PSA6_SOYBN Proteasome subunit alpha type-6; TrEMBL-Plants: tr|I3T518|I3T518_LOTJA Proteasome subunit alpha type; Found in the gene: LotjaGi3g1v0323300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03754 | CDD | 1 | 50.00 |