Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR035435

Source: InterPro

Description

IPR035435 is a Diphthamide synthesis DHP1/DPH2, eukaryotes and archaea.

<p>This entry includes diphthamide synthesis DPH1 from eukaryotes and archaea and DPH2 from archaea.</p> <p>Archaeal and eukaryotic translation elongation factor 2 (EF-2) contain a unique posttranslationally modified histidine residue called diphthamide, which become the target for ADP-ribosylation by diphtheria toxin [[cite:PUB00017070]]. DPH1 catalyzes the first step of diphthamide biosynthesis and is required for the modification of EF-2 [[cite:PUB00017070]]. The human DPH1 is also known as OVCA1 (for ovarian cancer gene 1), a tumour suppressor gene that plays a crucial role in the regulation of cell proliferation, embryonic development, and tumorigenesis [[cite:PUB00085370]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0017183
Biological process Peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0448400.1
– Diphthamide biosynthesis protein; TAIR: AT5G62030.1 diphthamide synthesis DPH2 family protein; Swiss-Prot: sp|Q54PW5|DPH1_DICDI Diphthamide biosynthesis protein 1; TrEMBL-Plants: tr|G7K6J3|G7K6J3_MEDTR Diphthamide biosynthesis protein; Found in the gene: LotjaGi2g1v0448400
Domains
20
LotjaGi2g1v0448400.2
– Diphthamide biosynthesis protein; TAIR: AT5G62030.1 diphthamide synthesis DPH2 family protein; Swiss-Prot: sp|Q54PW5|DPH1_DICDI Diphthamide biosynthesis protein 1; TrEMBL-Plants: tr|G7K6J3|G7K6J3_MEDTR Diphthamide biosynthesis protein; Found in the gene: LotjaGi2g1v0448400
Domains
20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00322 TIGRFAM 1 50.00