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IPR035584 is a Amidophosphoribosyltransferase, N-terminal.
<p>This glutaminase domain is found at the N-terminal of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (GPATase), also known as amidophosphoribosyltransferase. The glutaminase domain catalyses amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolysed to glutamic acid and ammonia.</p> <p>Purine nucleotides are synthesised both via the de novo pathway and via the salvage pathway and are vital for cell functions and cell proliferation through DNA and RNA syntheses and ATP energy supply. Amidophosphoribosyltransferase ([ec:2.4.2.14]) is the rate-limiting enzyme in the de novo pathway of purine ribonucleotide synthesis and is regulated by feedback inhibition by AMP and GMP [[cite:PUB00033234]]. <reaction>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O</reaction></p> <p>This enzyme crystallises as a homotetramer, but can also exist as a homodimer [[cite:PUB00085614]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Amidophosphoribosyltransferase; TAIR: AT2G16570.1 GLN phosphoribosyl pyrophosphate amidotransferase 1; Swiss-Prot: sp|P52418|PUR1_SOYBN Amidophosphoribosyltransferase, chloroplastic; TrEMBL-Plants: tr|A0A0L9V6R9|A0A0L9V6R9_PHAAN Amidophosphoribosyltransferase; Found in the gene: LotjaGi1g1v0562400 | 21 | ||
| – | Amidophosphoribosyltransferase; TAIR: AT2G16570.1 GLN phosphoribosyl pyrophosphate amidotransferase 1; Swiss-Prot: sp|P52418|PUR1_SOYBN Amidophosphoribosyltransferase, chloroplastic; TrEMBL-Plants: tr|A0A0L9V6R9|A0A0L9V6R9_PHAAN Amidophosphoribosyltransferase; Found in the gene: LotjaGi1g1v0562400 | 21 | ||
| – | Amidophosphoribosyltransferase; TAIR: AT2G16570.1 GLN phosphoribosyl pyrophosphate amidotransferase 1; Swiss-Prot: sp|Q9SI61|ASE1_ARATH Amidophosphoribosyltransferase 1, chloroplastic; TrEMBL-Plants: tr|G7JL07|G7JL07_MEDTR GLN phosphoribosyl pyrophosphate amidotransferase; Found in the gene: LotjaGi3g1v0515700 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |