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IPR035654 is a Elongation factor 4, domain IV.
<p>Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly [[cite:PUB00056782], [cite:PUB00056783]]. Elongation factor 4 binds to ribosomes in a GTP-dependent manner. The eukaryotic homologue is known as GUF1 and promotes protein synthesis in chloroplasts and mitochondria [[cite:PUB00056784]].</p> <p>EF4 has six domains, of which four (I, II, III, and V) are homologous to corresponding domains in EF-G [[cite:PUB00050954], [cite:PUB00085773], [cite:PUB00085883]]. This entry represents domain IV of EF4, homologous to domain V of EF-G.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Elongation factor 4; TAIR: AT5G08650.1 Small GTP-binding protein; Swiss-Prot: sp|A5B4D2|GUFP_VITVI Translation factor GUF1 homolog, chloroplastic; TrEMBL-Plants: tr|A0A0S3REW3|A0A0S3REW3_PHAAN Translation factor GUF1 homolog, chloroplastic; Found in the gene: LotjaGi1g1v0327700 | 37 | ||
| – | Elongation factor 4; TAIR: AT5G39900.1 Small GTP-binding protein; Swiss-Prot: sp|B9RUN8|GUF1_RICCO Translation factor GUF1 homolog, mitochondrial; TrEMBL-Plants: tr|A0A151TAY4|A0A151TAY4_CAJCA Translation factor GUF1 homolog, mitochondrial; Found in the gene: LotjaGi1g1v0500000 | 36 | ||
| – | Elongation factor 4; TAIR: AT5G39900.1 Small GTP-binding protein; Swiss-Prot: sp|B9RUN8|GUF1_RICCO Translation factor GUF1 homolog, mitochondrial; TrEMBL-Plants: tr|A0A151TAY4|A0A151TAY4_CAJCA Translation factor GUF1 homolog, mitochondrial; Found in the gene: LotjaGi1g1v0500000 | 36 | ||
| – | Elongation factor 4; TAIR: AT5G39900.1 Small GTP-binding protein; Swiss-Prot: sp|B9RUN8|GUF1_RICCO Translation factor GUF1 homolog, mitochondrial; TrEMBL-Plants: tr|A0A151TAY4|A0A151TAY4_CAJCA Translation factor GUF1 homolog, mitochondrial; Found in the gene: LotjaGi1g1v0500000 | 36 | ||
| – | Elongation factor 4; TAIR: AT5G39900.1 Small GTP-binding protein; Swiss-Prot: sp|B9RUN8|GUF1_RICCO Translation factor GUF1 homolog, mitochondrial; TrEMBL-Plants: tr|A0A151TAY4|A0A151TAY4_CAJCA Translation factor GUF1 homolog, mitochondrial; Found in the gene: LotjaGi1g1v0500000 | 36 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16260 | CDD | 1 | 20.00 |