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IPR035778 is a Heterogeneous nuclear ribonucleoprotein U, SPRY domain.
<p>This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of heterogeneous nuclear ribonucleoprotein U (hnRNP U) and hnRNP U-like proteins 1 and 2.</p> <p>hnRNP U contains three conserved domains: a SAF-Box that binds to AT-rich chromosomal region known as a scaffold- or matrix-attachment region (S/MAR), SPRY (Spla and Ryanodine receptor) domain of unknown function, and RGG (arginine-glycine-glycine) RNA-binding domain. hnRNP U is involved in transcription [[cite:PUB00086168]], alternative splicing [[cite:PUB00086169]] and inactivation one of the two female X chromosomes [[cite:PUB00086170]]. hnRNP U-like proteins 1 and 2 play key roles in cellular responses to double-strand breaks (DSBs) [[cite:PUB00086171], [cite:PUB00086172]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Heterogeneous nuclear ribonucleoprotein U-like protein 1; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9BUJ2|HNRL1_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 1; TrEMBL-Plants: tr|I1MEA2|I1MEA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0339000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |