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IPR043136 is a B30.2/SPRY domain superfamily.
<p>The B30.2 domain was first identified as a protein domain encoded by an exon (named B30-2) in the Homo sapiens class I major histocompatibility complex region [[cite:PUB00033710]], whereas the SPRY domain was first identified in a Dictyostelium discoideum kinase splA and mammalian calcium-release channels ryanodine receptors [[cite:PUB00005467]]. B30.2 domain consists of PRY and SPRY subdomains. The SPRY domains (after SPla and the RYanodine Receptor) are shorter at the N terminus than the B30.2 domains. The ~200-residue B30.2/SPRY (for B30.2 and/or SPRY) domain is present in a large number of proteins with diverse individual functions in different biological processes. The B30.2/SPRY domain in these proteins is likely to function through protein-protein interaction [[cite:PUB00033711]]. The N-terminal ~60 residues of B30.2/SPRY domains are poorly conserved and, as a consequence, a new domain name PRY was coined for a group of similar sequence segments N-terminal to the SPRY domains [[cite:PUB00033711]]. The B30.2/SPRY domain contains three highly conserved motifs (LDP, WEVE and LDYE) [[cite:PUB00033712]]. The B30.2/SPRY domain adopts a highly distorted, compact β-sandwich fold with two additional short β-helices at the N terminus. The β-sandwich of the B30.2/SPRY domain consists of two layers of β-sheets: sheet A composed of eight strands and sheet B composed of seven strands. All the β-strands are in antiparallel arrangement [[cite:PUB00033711]]. The 5th β-strand corresponding to WEVE motif [[cite:PUB00033713]]. Both the N- and C-terminal ends of the B30.2/SPRY domains in general are close to each other [[cite:PUB00033711]].</p> <p>This superfamily also matches diverse E3 ubiquitin-protein ligases. This protein is involved in the apoptosis process [[cite:PUB00084879], [cite:PUB00093725]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400 | 24 | ||
| – | E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400 | 24 | ||
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|I1LPA8|I1LPA8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 16 | ||
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|V7ADB2|V7ADB2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 13 | ||
| – | Ran-binding protein 10; TAIR: AT1G35470.2 SPla/RYanodine receptor (SPRY) domain-containing protein; Swiss-Prot: sp|Q1LUS8|RBP10_DANRE Ran-binding protein 10; TrEMBL-Plants: tr|I1LNN2|I1LNN2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0556900 | 22 | ||
| – | Heterogeneous nuclear ribonucleoprotein U-like protein 1; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9BUJ2|HNRL1_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 1; TrEMBL-Plants: tr|I1MEA2|I1MEA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0339000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |