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IPR003877 is a SPRY domain.
<p>The SPRY domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development [[cite:PUB00041714], [cite:PUB00085899], [cite:PUB00095661]]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region [[cite:PUB00085899]]. SPRY/B30.2 structures revealed a bent β-sandwich fold comprised of two β-sheets. The PRY domain consists of three β-strands tightly packed against ten other β-strands which form the SPRY component of the B30.2 domain. The β-strands are linked by loops and form two anti-parallel β-sheets [[cite:PUB00085899]]. Distant homologues are domains in butyrophilin/marenostrin/pyrin [[cite:PUB00005467]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein ssh4 [Medicago truncatula] gi|357465591|ref|XP_003603080.1| | 12 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase RKP-like [Glycine max] gi|356516283|ref|XP_003526825.1| | 20 | ||
| – | PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2-like [Glycine max] gi|356543622|ref|XP_003540259.1| | 10 | ||
| – | PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2-like [Glycine max] gi|356543622|ref|XP_003540259.1| | 10 | ||
| – | PREDICTED: ran-binding protein 10-like [Glycine max] gi|356541828|ref|XP_003539374.1| | 20 | ||
| – | PREDICTED: ran-binding protein 10-like [Glycine max] gi|356541828|ref|XP_003539374.1| | 10 | ||
| – | Protein ssh4 [Medicago truncatula] gi|357437749|ref|XP_003589150.1| | 8 | ||
| – | E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400 | 24 | ||
| – | E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400 | 24 | ||
| – | SPla/RYanodine receptor (SPRY) domain protein; TAIR: AT4G06536.1 SPla/RYanodine receptor (SPRY) domain-containing protein; Swiss-Prot: sp|Q4WRW0|SSH4_ASPFU Protein ssh4; TrEMBL-Plants: tr|V7AT08|V7AT08_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0357200 | 12 | ||
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|I1LPA8|I1LPA8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 16 | ||
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|V7ADB2|V7ADB2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 13 | ||
| – | Ran-binding protein 10; TAIR: AT1G35470.2 SPla/RYanodine receptor (SPRY) domain-containing protein; Swiss-Prot: sp|Q1LUS8|RBP10_DANRE Ran-binding protein 10; TrEMBL-Plants: tr|I1LNN2|I1LNN2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0556900 | 22 | ||
| – | SPla/RYanodine receptor (SPRY) domain protein; TAIR: AT4G06536.1 SPla/RYanodine receptor (SPRY) domain-containing protein; Swiss-Prot: sp|Q4WRW0|SSH4_ASPFU Protein ssh4; TrEMBL-Plants: tr|K7M5N2|K7M5N2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0029000 | 8 | ||
| – | Heterogeneous nuclear ribonucleoprotein U-like protein 1; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9BUJ2|HNRL1_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 1; TrEMBL-Plants: tr|I1MEA2|I1MEA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0339000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |