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IPR036529 is a Coactivator CBP, KIX domain superfamily.
<p>Transcriptional activators are believed to stimulate gene expression via protein-protein interactions with the basal machinery. The cAMP-regulated transcription factor CREB has been shown to stimulate target gene expression, in part by associating with the coactivator paralogues p300 and CREB binding protein (CBP). CBP and P300 bind to the Ser-133-phosphorylated kinase-inducible domain (KID) of CREB via a region of approximately 90 residues referred to as the KIX domain, which is highly conserved in CBP homologues from Caenorhabditis elegans and Drosophila melanogaster. In addition to CREB, the KIX domain of CBP also recognises the transactivation domains of other nuclear factors, including Myb, Jun, cubitus interruptus, and HTLV-1 virally encoded Tax protein. Thus the KIX domain appears to be a common docking site on CBP for many transcriptional activators. The KIX domain is found in association with other domains, such as the bromodomain, the ZZ-type zinc finger, or the TAZ-type zinc finger [[cite:PUB00018422], [cite:PUB00006396]].</p> <p>The KIX domain of CBP is composed of three mutually interacting α helices, designated alpha1, alpha2 and alpha3, and two short 3(10) helices G1 and G2, that together with the interconnecting loops define a compact structural domain with an extensive hydrophobic core. Helices alpha1 and alpha3 constitute the primary interacting surface for the phosphorylated KID domain (pKID), forming a hydrophobic patch on the protein surface that is large enough to accommodate up to 3 turns of an amphipathic α helix, designated alphaB, in pKID. A second α helix in pKID, referred to as alphaA, interacts with a different face of the alpha3 helix of KIX. The two helices of pKID are arranged at an angle of about 90 degree and essentially wrap around the alpha3 helix of KIX [[cite:PUB00018422], [cite:PUB00006396]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transcription coregulator activity | A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT2G10440.2 mediator of RNA polymerase II transcription subunit; Swiss-Prot: sp|Q9SHV7|MD15C_ARATH Probable mediator of RNA polymerase II transcription subunit 15c; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT2G10440.2 mediator of RNA polymerase II transcription subunit; Swiss-Prot: sp|Q9SHV7|MD15C_ARATH Probable mediator of RNA polymerase II transcription subunit 15c; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT2G10440.2 mediator of RNA polymerase II transcription subunit; Swiss-Prot: sp|Q9SHV7|MD15C_ARATH Probable mediator of RNA polymerase II transcription subunit 15c; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT1G15780.3 mediator of RNA polymerase II transcription subunit 15a-like protein; Swiss-Prot: sp|F4I171|MD15A_ARATH Mediator of RNA polymerase II transcription subunit 15a; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT2G10440.2 mediator of RNA polymerase II transcription subunit; Swiss-Prot: sp|Q9SHV7|MD15C_ARATH Probable mediator of RNA polymerase II transcription subunit 15c; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT1G15780.1 mediator of RNA polymerase II transcription subunit 15a-like protein; Swiss-Prot: sp|F4I171|MD15A_ARATH Mediator of RNA polymerase II transcription subunit 15a; TrEMBL-Plants: tr|G7IM96|G7IM96_MEDTR Transcription cofactor, putative; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT1G15780.1 mediator of RNA polymerase II transcription subunit 15a-like protein; Swiss-Prot: sp|F4I171|MD15A_ARATH Mediator of RNA polymerase II transcription subunit 15a; TrEMBL-Plants: tr|A0A0S3SF80|A0A0S3SF80_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0006200 | 8 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT1G15780.1 mediator of RNA polymerase II transcription subunit 15a-like protein; Swiss-Prot: sp|F4I171|MD15A_ARATH Mediator of RNA polymerase II transcription subunit 15a; TrEMBL-Plants: tr|K7M0K0|K7M0K0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0312400_LC | 5 | ||
| – | Mediator of RNA polymerase II transcription subunit 15a, putative; TAIR: AT1G15780.1 mediator of RNA polymerase II transcription subunit 15a-like protein; Swiss-Prot: sp|F4I171|MD15A_ARATH Mediator of RNA polymerase II transcription subunit 15a; TrEMBL-Plants: tr|K7L7Z4|K7L7Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0353400 | 8 | ||
| – | Histone acetyltransferase; TAIR: AT3G24150.1 hypothetical protein; Swiss-Prot: sp|Q12TC8|DNAA_SHEDO Chromosomal replication initiator protein DnaA; TrEMBL-Plants: tr|I1LZP3|I1LZP3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0273400 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |