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IPR036784 is a Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily.
<p>Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. Regulating the activity of the branched-chain alpha-ketoacid dehydrogenase (BCDH) complex is the primary means by which these processes are coordinated. BCDH kinase regulates BCDH by phosphorylation, thereby inactivating it when synthesis is required.</p> <p>The N-terminal domain of the alpha-ketoacid dehydrogenase kinase has a bromodomain-like fold, which consists of four helices arranged in bundle with minor mirror variant of up-and-down topology.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|A0A0S3RH61|A0A0S3RH61_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0313600_LC | 19 | ||
| – | Mitochondrial pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|I3S8V4|I3S8V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0217100 | 19 | ||
| – | Mitochondrial pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|I3S8V4|I3S8V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0217100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16929 | CDD | 1 | 33.33 |