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IPR039028 is a PDK/BCKDK protein kinase.
<p>This entry includes [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase (BCKDK) and [Pyruvate dehydrogenase (acetyl-transferring)] kinase (PDK). BCKDK is a serine/threonine-protein kinase component of macronutrients metabolism. It forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle [[cite:PUB00088772], [cite:PUB00153164], [cite:PUB00153165]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|A0A0S3RH61|A0A0S3RH61_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0313600_LC | 19 | ||
| – | Mitochondrial pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|I3S8V4|I3S8V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0217100 | 19 | ||
| – | Mitochondrial pyruvate dehydrogenase kinase; TAIR: AT3G06483.1 pyruvate dehydrogenase kinase; Swiss-Prot: sp|Q9SBJ1|PDK_ARATH [Pyruvate dehydrogenase ](acetyl-transferring)] kinase, mitochondrial; TrEMBL-Plants: tr|I3S8V4|I3S8V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0217100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16929 | CDD | 1 | 33.33 |