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IPR037143

Source: InterPro

Description

IPR037143 is a 4'-phosphopantetheinyl transferase domain superfamily.

<p>The 4'-phosphopantetheinyl transferase domain superfamily of proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [[cite:PUB00002924]]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the Sfp type such as SFP_BACSU. The structure of the Sfp type is known [[cite:PUB00011221]], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000287
Molecular function Magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
Subterm of
GO:0008897
Molecular function Holo-[acyl-carrier-protein] synthase activity Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
Subterm of

Associated Lotus transcripts 10

Transcript Name Description Predicted domains Domain count
LotjaGi5g1v0096600.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600
Domains
7
LotjaGi5g1v0096600.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600
Domains
7
LotjaGi6g1v0021000.1
– 4'-phosphopantetheinyl transferase family protein; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|B2RYJ4|ADPPT_RAT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A0B2RKT0|A0A0B2RKT0_GLYSO L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0021000
Domains
7
LotjaGi6g1v0267400_LC.1
– Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC
Domains
7
LotjaGi6g1v0267400_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.4 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P37695|HETI_NOSS1 4'-phosphopantetheinyl transferase HetI; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0267400_LC
Domains
7
LotjaGi6g1v0267400_LC.3
– Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC
Domains
7
LotjaGi6g1v0275500_LC.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC
Domains
7
LotjaGi6g1v0275500_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC
Domains
7
LotjaGi6g1v0276000_LC.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39135|SFP_BACSU 4'-phosphopantetheinyl transferase sfp; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0276000_LC
Domains
5
LotjaGi6g1v0276000_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39135|SFP_BACSU 4'-phosphopantetheinyl transferase sfp; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0276000_LC
Domains
5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF56214 SUPERFAMILY 1 10.00