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IPR008278 is a 4'-phosphopantetheinyl transferase domain.
<p>The 4'-phosphopantetheinyl transferase superfamily of proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [[cite:PUB00002924]]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the Sfp type such as SFP_BACSU. The structure of the Sfp type is known [[cite:PUB00011221]], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. | ||
| Molecular function | Holo-[acyl-carrier-protein] synthase activity | Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase-like [Glycine max] gi|356555754|ref|XP_003546195.1| | 6 | ||
| – | 4'-phosphopantetheinyl transferase [Medicago truncatula] gi|357520283|ref|XP_003630430.1| | 6 | ||
| – | 4'-phosphopantetheinyl transferase [Medicago truncatula] gi|357520285|ref|XP_003630431.1| | 5 | ||
| – | PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1| | 5 | ||
| – | PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1| | 10 | ||
| – | PREDICTED: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase-like [Glycine max] gi|356555754|ref|XP_003546195.1| | 6 | ||
| – | PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1| | 6 | ||
| – | PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1| | 6 | ||
| – | 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600 | 7 | ||
| – | 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600 | 7 | ||
| – | 4'-phosphopantetheinyl transferase family protein; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|B2RYJ4|ADPPT_RAT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A0B2RKT0|A0A0B2RKT0_GLYSO L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0021000 | 7 | ||
| – | Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC | 7 | ||
| – | 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.4 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P37695|HETI_NOSS1 4'-phosphopantetheinyl transferase HetI; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0267400_LC | 7 | ||
| – | Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC | 7 | ||
| – | 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC | 7 | ||
| – | 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56214 | SUPERFAMILY | 1 | 6.25 |