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IPR037588 is a Target of rapamycin complex subunit LST8.
<p>This entry represents target of rapamycin complex subunit LST8 (MLST8 or GbetaL), a component of both mTORC1 and mTORC2, complexes that regulate cell growth in response to nutrients. The mTORC1 complex consists of MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC2 complex contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR [[cite:PUB00015261]]. In mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity [[cite:PUB00087296]].</p> <p>This entry also includes the target of rapamycin complex subunit wat1 (pop3 or wat1) from Schizosaccharomyces pombe, which is also a component of yeast TORC1 and TORC2 complexes. The subunits of TORC1 in fission yeasts are known as mip1, pop3/wat1, tco89, toc1 and tor2; and the subunits of the TORC2 complex are bit61, pop3/wat1, sin1, ste20 and tor1 [[cite:PUB00044236]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | TOR signaling | A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. | ||
| Cellular component | TORC1 complex | A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. | ||
| Cellular component | TORC2 complex | A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | WD40 repeat-like protein; TAIR: AT3G18140.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q54D08|LST8_DICDI Protein LST8 homolog; TrEMBL-Plants: tr|I3S6V4|I3S6V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0320200 | 18 | ||
| – | WD40 repeat-like protein; TAIR: AT3G18140.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q54D08|LST8_DICDI Protein LST8 homolog; TrEMBL-Plants: tr|I3S6V4|I3S6V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0320200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00200 | CDD | 1 | 50.00 |