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IPR037683 is a Rmd5, degenerated RING (dRING) finger.
<p>Rmd5 (also known as Gid2) is an E3 ubiquitin ligase containing a Lissencephaly type-1-like homology motif (LisH), a C-terminal to LisH motif (CTLH) domain, and a degenerated RING finger that is characterised by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues compared with the classic C3H2C3-/C3HC4-type RING fingers [[cite:PUB00087471]]. It forms the heterodimeric E3 ligase unit of the glucose induced degradation deficient (GID) complex with Gid9 (also known as Fyv10), which has a degenerated RING finger as well [[cite:PUB00033377]].</p> <p>The GID complex triggers polyubiquitylation and subsequent proteasomal degradation of the gluconeogenic enzymes fructose-1, 6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK), and cytoplasmic malate dehydrogenase (c-MDH). Moreover, Rmd5p can form the GID complex with the other six Gid proteins, including Gid1/Vid30, Gid4/Vid24, Gid5/Vid28, Gid7, Gid8, and Gid9/Fyv10. The GID complex in which the seven Gid proteins reside functions as a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism [[cite:PUB00063312]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein RMD5 like A; TAIR: AT4G37880.1 LisH/CRA/RING-U-box domains-containing protein; Swiss-Prot: sp|Q6GLP4|RMD5A_XENLA Protein RMD5 homolog A; TrEMBL-Plants: tr|K0BV36|K0BV36_LOTJA SIE3; Found in the gene: LotjaGi3g1v0179400 | 20 | ||
| – | Protein RMD5 like A; TAIR: AT4G37880.1 LisH/CRA/RING-U-box domains-containing protein; Swiss-Prot: sp|Q6GLP4|RMD5A_XENLA Protein RMD5 homolog A; TrEMBL-Plants: tr|K0BV36|K0BV36_LOTJA SIE3; Found in the gene: LotjaGi3g1v0179400 | 20 | ||
| – | Protein RMD5 like A; TAIR: AT4G37880.1 LisH/CRA/RING-U-box domains-containing protein; Swiss-Prot: sp|Q640V2|RMD5A_XENTR Protein RMD5 homolog A; TrEMBL-Plants: tr|A0A151S0Z4|A0A151S0Z4_CAJCA Protein RMD5 isogeny A; Found in the gene: LotjaGi6g1v0346500 | 22 | ||
| – | Protein RMD5 like A; TAIR: AT4G37880.1 LisH/CRA/RING-U-box domains-containing protein; Swiss-Prot: sp|Q640V2|RMD5A_XENTR Protein RMD5 homolog A; TrEMBL-Plants: tr|A0A151S0Z4|A0A151S0Z4_CAJCA Protein RMD5 isogeny A; Found in the gene: LotjaGi6g1v0346500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16652 | CDD | 1 | 25.00 |